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Encyclopedia of AIDS pp 1–17Cite as

HIV-2: Lessons from the Dakar Cohort

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Definitions

Acquired immunodeficiency syndrome (AIDS): a clinical syndrome caused by the human immunodeficiency virus (HIV). Its pathogenesis is related to a qualitative and quantitative impairment of the immune system, particularly a reduction of the CD4+ helper T lymphocyte cell count (surrogate marker of the disease). After an average of 10 years if untreated, HIV+ individuals can develop opportunistic diseases (i.e., infections and cancers rarely detected in people with normal immune systems). The natural history of the disease can be dramatically modified with administration of combination therapy composed of antiretroviral (ARV) drugs. This is seen in both HIV-1 and HIV-2 diseases.

Beta chemokines: a family of proteins produced in response to acute or chronic inflammation to attract a variety of white blood cells. They are characterized by a double cysteine (C–C) in their primary sequence. They bind to cellular targets by specific beta-chemokine receptors that are one of the...

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Author information

Authors and Affiliations

  1. Department of Immunology and Infectious Disease, Harvard School of Public Health, 651 Huntington Avenue, Boston, MA, 02115, USA

    Phyllis J. Kanki

  2. Department of Virologie, Cheikh Anta Diop Université, CHU Le Dantec, BP 7325, Dakar, Senegal

    Souleymane Mboup

Authors
  1. Phyllis J. Kanki
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  2. Souleymane Mboup
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Corresponding author

Correspondence to Phyllis J. Kanki .

Editor information

Editors and Affiliations

  1. Dept. Cell & Molecular Biology, Northwestern University, Feinberg School of Medicine, Chicago, Illinois, USA

    Thomas J. Hope

  2. Office of Graduate and Postdoctoral Studies, University of Miami, Miller School of Medicine, Miami, Florida, USA

    Mario Stevenson

  3. University of California, San Diego Dept. Pathology, La Jolla, California, USA

    Douglas Richman

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Kanki, P.J., Mboup, S. (2013). HIV-2: Lessons from the Dakar Cohort. In: Hope, T., Stevenson, M., Richman, D. (eds) Encyclopedia of AIDS. Springer, New York, NY. https://doi.org/10.1007/978-1-4614-9610-6_45-1

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  • DOI: https://doi.org/10.1007/978-1-4614-9610-6_45-1

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  • Online ISBN: 978-1-4614-9610-6

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Chapter history

  1. Latest

    HIV-2: Lessons from the Dakar Cohort
    Published:
    01 October 2014

    DOI: https://doi.org/10.1007/978-1-4614-9610-6_45-1

  2. Original

    Immunological Responses to Antiretroviral Therapy
    Published:
    30 September 2014

    DOI: https://doi.org/10.1007/978-1-4614-9610-6_301-1

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