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Prevention of Mother-to-Child Transmission of AIDS

  • Living reference work entry
  • First Online:
Encyclopedia of AIDS

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Definition

The role of antiretroviral treatment (ART) in pregnant and breastfeeding women for prevention of mother-to-child transmission (pMTCT) of HIV has become simple: control of maternal HIV viremia with highly active combination ART effectively blocks MTCT. Details, however, are complex. Lifetime optimal health for mother and child must be balanced with potential toxicities associated with such treatment. The pharmacokinetics of ART in pregnancy and transfer of ART through the placenta and in breast milk are also important considerations in optimizing the health of mother and infant. Management of opportunistic infections in the setting of pregnancy, and limitations in access to, and lack of safety data for newer combination therapies also impact the complexity of managing HIV in pregnancy. ART as preexposure prophylaxis (PreP) for serodiscordant couples planning pregnancies and the use of PreP in serodiscordant couples during pregnancy and breastfeeding have emerged as strategies...

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Author information

Authors and Affiliations

  1. Department of Medicine, Division of Infectious Diseases, Weill Cornell Medical College, New York, NY, USA

    Mary Vogler

  2. Department of Obstetrics & Gynecology and Women’s Health, Division of Maternal-Fetal Medicine, Albert Einstein College of Medicine, Bronx, NY, USA

    Karen Beckerman

Authors
  1. Mary Vogler
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  2. Karen Beckerman
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Corresponding author

Correspondence to Mary Vogler .

Editor information

Editors and Affiliations

  1. Dept. Cell & Molecular Biology, Northwestern University, Feinberg School of Medicine, Chicago, Illinois, USA

    Thomas J. Hope

  2. Office of Graduate and Postdoctoral Studies, University of Miami, Miller School of Medicine, Miami, Florida, USA

    Mario Stevenson

  3. University of California, San Diego Dept. Pathology, La Jolla, California, USA

    Douglas Richman

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Vogler, M., Beckerman, K. (2015). Prevention of Mother-to-Child Transmission of AIDS. In: Hope, T., Stevenson, M., Richman, D. (eds) Encyclopedia of AIDS. Springer, New York, NY. https://doi.org/10.1007/978-1-4614-9610-6_449-1

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  • DOI: https://doi.org/10.1007/978-1-4614-9610-6_449-1

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  • Publisher Name: Springer, New York, NY

  • Online ISBN: 978-1-4614-9610-6

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