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Antiretroviral Therapy for HIV-Infected Infants, Children, and Adolescents in Resource-Rich Settings

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Encyclopedia of AIDS

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Definition

The treatment of HIV-infected infants, children, and adolescents (ICA) mandates the use of a combination of antiretroviral drugs (ARVs) from two or more classes targeting different steps in the HIV life cycle. These classes include nucleoside reverse transcriptase inhibitors (NRTIs), nonnucleoside reverse transcriptase inhibitors (NNRTIs), protease inhibitors (PIs), integrase strand-transfer inhibitor (INSTI), and attachment/entry inhibitors. There are now 21 Food and Drug Administration (FDA) approved therapeutic agents available for pediatric and adolescent populations ≤17 years of age, with several of those medications available in child-friendly formulations such as suspensions, chewable tablets, and powders. In qualifying adolescents, the use of multiple ARVs combined into a single tablet, also known as single tablet regimens (STRs), may also be considered. The goals of combination antiretroviral therapy (cART), recommendations of when and why to initiate therapy, an...

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Author information

Authors and Affiliations

  1. Division of Pediatric Infectious Diseases, Department of Pediatrics, NY Presbyterian Hospital – Weill Cornell Medical College, New York, NY, USA

    Sima S. Toussi

  2. Division of Pediatric Infectious Diseases, Jacobi Medical Center, Albert Einstein College of Medicine, Yeshiva University, 1400 Pelham Parkway South, Bronx, NY, 10461, USA

    Michael Rosenberg

Authors
  1. Sima S. Toussi
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  2. Michael Rosenberg
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Correspondence to Sima S. Toussi .

Editor information

Editors and Affiliations

  1. Dept. Cell & Molecular Biology, Northwestern University, Feinberg School of Medicine, Chicago, Illinois, USA

    Thomas J. Hope

  2. Office of Graduate and Postdoctoral Studies, University of Miami, Miller School of Medicine, Miami, Florida, USA

    Mario Stevenson

  3. University of California, San Diego Dept. Pathology, La Jolla, California, USA

    Douglas Richman

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Toussi, S., Rosenberg, M. (2016). Antiretroviral Therapy for HIV-Infected Infants, Children, and Adolescents in Resource-Rich Settings. In: Hope, T., Stevenson, M., Richman, D. (eds) Encyclopedia of AIDS. Springer, New York, NY. https://doi.org/10.1007/978-1-4614-9610-6_448-1

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  • DOI: https://doi.org/10.1007/978-1-4614-9610-6_448-1

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  • Online ISBN: 978-1-4614-9610-6

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