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HIV Coreceptor Tropism in Different Reservoirs

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  • First Online:
Encyclopedia of AIDS

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Definition

For Retroviridae like human immunodeficiency viruses (HIV), the latent reservoir consists of inactive forms of the provirus that is the DNA version of the viral genome integrated at a random position in the host genome. After infection, HIV rapidly disseminates through the body and HIV reservoir is consisted of one or multiple viral reservoirs (cell types or tissues). Despite the development of successful treatment of HIV-infected individuals and the capacity to reduce HIV in the blood to undetectable levels, it has not been yet possible to eradicate HIV from the body due to the persistence of viral reservoirs. CD4+ T cells are thought to be the most significant cellular reservoir for HIV-1, but other reservoirs can contribute to virus persistence (Brenchley et al. 2004). Furthermore, the establishment of viral persistence and latent reservoirs could also depend on the HIV tropism and differential expression of coreceptor on the surface of cells.

HIV-1 entry into CD4+ T...

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Authors and Affiliations

  1. Sorbonne Universités, UPMC Univ Paris 06, INSERM, Institut Pierre Louis d’épidémiologie et de Santé Publique (IPLESP UMRS 1136), F-75005, Paris, France

    Cathia Soulie & Anne-Geneviève Marcelin

  2. Laboratoire de Virologie, AP-HP, Groupe hospitalier Pitié Salpêtrière, F-75013, Paris, France

    Cathia Soulie & Anne-Geneviève Marcelin

Authors
  1. Cathia Soulie
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  2. Anne-Geneviève Marcelin
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Correspondence to Cathia Soulie .

Editor information

Editors and Affiliations

  1. Dept. Cell & Molecular Biology, Northwestern University, Feinberg School of Medicine, Chicago, Illinois, USA

    Thomas J. Hope

  2. Office of Graduate and Postdoctoral Studies, University of Miami, Miller School of Medicine, Miami, Florida, USA

    Mario Stevenson

  3. University of California, San Diego Dept. Pathology, La Jolla, California, USA

    Douglas Richman

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Soulie, C., Marcelin, AG. (2015). HIV Coreceptor Tropism in Different Reservoirs. In: Hope, T., Stevenson, M., Richman, D. (eds) Encyclopedia of AIDS. Springer, New York, NY. https://doi.org/10.1007/978-1-4614-9610-6_438-1

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  • DOI: https://doi.org/10.1007/978-1-4614-9610-6_438-1

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  • Publisher Name: Springer, New York, NY

  • Online ISBN: 978-1-4614-9610-6

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