HIV Compartments and Viral Rebound During Treatment Interruption
One of the main challenging characteristics of HIV is its extensive genetic diversity. This diversity is apparent across geography as represented by differing clades, but on a smaller scale exists within an individual. Viral phylogenetic studies within the same individual have shown diversity and divergence of the HIV virus in the multiple cell types and tissues analyzed. These subpopulations are known as viral quasispecies (Blackard 2012). The local environment present in the tissues influences the evolution of the quasispecies and subsequently impacts cellular tropism (i.e., higher affinity to macrophages from brain-derived virus), affects the response to antiretroviral therapy (ART), and ultimately, could affect eradication strategies.
A compartment has been defined as an anatomical site in which the virus is present, and there is limited exchange of viral genetic information with other sites and may contain compartment-specific viral sequences (Eisele and Siliciano 2012)...
KeywordsDementia Germinal Posit Washout Neurotoxicity
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