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HIV Reservoirs Within the Lungs

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  • First Online:
Encyclopedia of AIDS

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Definition

Over recent years, efforts aimed at understanding HIV persistence have intensified, with the hopes that this understanding will provide the platform for developing strategies to eliminate HIV reservoirs. Traditionally, efforts have focused on the gut-associated lymphoid tissue, which is the largest HIV reservoir within the body, and the genitourinary tract due to implications for HIV transmission. The central nervous system has also been a focus of study due to interest in the ability of the blood-brain barrier to protect the brain from various pathogens, clinical observations surrounding HIV-associated neurocognitive disorders, and questions regarding antiretroviral penetration into the cerebrospinal fluid and brain parenchyma. The lungs as HIV reservoirs received greater attention in the pre-highly active antiretroviral therapy (HAART), whereby patients had indications for bronchoscopy due to active lung symptoms, compared to the HAART era whereby opportunistic infections...

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Authors and Affiliations

  1. Department of Medicine, Divisions of Infectious Diseases/Chronic Viral Illness Service and Lachine Hospital, McGill University Health Centre, 1001 Boul Decarie, Glen Site, H4A 3J1, Montreal, QC, Canada

    Cecilia T. Costiniuk

  2. Département des Sciences Biologiques et Centre de recherche BioMed, Université du Québec à Montréal (UQAM), 141, Ave President Kennedy, H3C 3P8, Montréal, Quebec, Canada

    Mohammad-Ali Jenabian

Authors
  1. Cecilia T. Costiniuk
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  2. Mohammad-Ali Jenabian
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Corresponding author

Correspondence to Cecilia T. Costiniuk .

Editor information

Editors and Affiliations

  1. Dept. Cell & Molecular Biology, Northwestern University, Feinberg School of Medicine, Chicago, Illinois, USA

    Thomas J. Hope

  2. Office of Graduate and Postdoctoral Studies, University of Miami, Miller School of Medicine, Miami, Florida, USA

    Mario Stevenson

  3. University of California, San Diego Dept. Pathology, La Jolla, California, USA

    Douglas Richman

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Costiniuk, C.T., Jenabian, MA. (2015). HIV Reservoirs Within the Lungs. In: Hope, T., Stevenson, M., Richman, D. (eds) Encyclopedia of AIDS. Springer, New York, NY. https://doi.org/10.1007/978-1-4614-9610-6_432-1

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  • DOI: https://doi.org/10.1007/978-1-4614-9610-6_432-1

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  • Publisher Name: Springer, New York, NY

  • Online ISBN: 978-1-4614-9610-6

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