Definitions
- Endemic mycoses:
-
Fungal infections that occur within specific geographic regions
- Immune reconstitution:
-
Improvement in cellular immune function consequent to potent antiretroviral therapy
- Prevention of disease:
-
Antimicrobial therapy or other methods to prevent initial infection
- Prevention of relapse:
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Antimicrobial therapy given after clinical disease has resolved
Introduction
This chapter will discuss three endemic mycoses, histoplasmosis, coccidioidomycosis, and paracoccidioidomycosis, which have been associated with HIV-related infections. All are dimorphic and reside as molds in the environment, and each occurs in specific geographic regions in the Western Hemisphere, although histoplasmosis can be found worldwide.
As the HIV epidemic spread and involved new geographic regions, endemic fungi became important causes of opportunistic infections. Because they exist in the environment, limiting exposure to these fungi is not easily achieved. While these fungi cause illness...
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Ampel, N.M. (2016). Treatment of Histoplasmosis, Coccidioidomycosis, and Paracoccidioidomycosis in Patients with HIV Infection. In: Hope, T., Stevenson, M., Richman, D. (eds) Encyclopedia of AIDS. Springer, New York, NY. https://doi.org/10.1007/978-1-4614-9610-6_418-1
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