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Encyclopedia of AIDS pp 1–12Cite as

Cryptococcosis and HIV

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Definition

Cryptococcus neoformans and Cryptococcus gattii are encapsulated yeasts found in the environment. Cryptococcus neoformans is classically isolated from the soil and from bird guano. Cryptococcus gattii has been isolated from plants and trees, classically eucalyptus trees. This fungus infrequently causes infection in healthy persons but is also an opportunistic pathogen in persons with defects in cell-mediated immunity, such as HIV. In HIV-infected persons, those with a CD4 < 100 cell/μL are at particular risk of developing cryptococcal infection. Cryptococcus yeasts are acquired through inhalation, with ubiquitous environmental exposure (Fig. 1). As the immune system weakens, from conditions such as HIV infection, organ transplantation, cirrhosis, or corticosteroid use, the fungus can disseminate from the lungs throughout the body, including the brain, skin, and other organs.

Fig. 1
figure 1

Biology of Cryptococcus. Cryptococcus lives in the environment (1), usually in association...

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Authors and Affiliations

  1. Division of Infectious Diseases and International Medicine, Department of Medicine, University of Minnesota, 2001 6th Street SE, 55455, Minneapolis, MN, USA

    Radha Rajasingham & David R. Boulware

Authors
  1. Radha Rajasingham
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  2. David R. Boulware
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Correspondence to Radha Rajasingham .

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Editors and Affiliations

  1. Dept. Cell & Molecular Biology, Northwestern University, Feinberg School of Medicine, Chicago, Illinois, USA

    Thomas J. Hope

  2. Office of Graduate and Postdoctoral Studies, University of Miami, Miller School of Medicine, Miami, Florida, USA

    Mario Stevenson

  3. University of California, San Diego Dept. Pathology, La Jolla, California, USA

    Douglas Richman

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Rajasingham, R., Boulware, D. (2016). Cryptococcosis and HIV. In: Hope, T., Stevenson, M., Richman, D. (eds) Encyclopedia of AIDS. Springer, New York, NY. https://doi.org/10.1007/978-1-4614-9610-6_417-1

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