Encyclopedia of AIDS

Living Edition
| Editors: Thomas J. Hope, Douglas Richman, Mario Stevenson

Natural History and Clinical Features of HIV-2 Infection

  • Kevin Peterson
Living reference work entry
DOI: https://doi.org/10.1007/978-1-4614-9610-6_39-1


A summary of the key literature on the virological, immunological, and clinical progression of HIV-2-infected individuals, with emphasis on the contrast between HIV-2 and HIV-1.

Natural History and Viral Load

The single most distinguishing feature of HIV-2 compared to HIV-1 is its much lower viral load set point. There are no data on the viral loads achieved during the acute phase of HIV-2 infection and less data than for HIV-1 on the viral loads maintained during chronic infection, limiting the precision of viral load estimates at a population level. The viral loads of individuals with untreated chronic HIV-2 infection show considerable variability. While a minority of those infected with HIV-2 have viral burdens typical of progressive HIV-1 infections, in approximately 80 % of HIV-2-infected individuals, viral loads remain very low or, in up to perhaps a third of cases, undetectable (Grant et al. 1997; van der Loeff et al. 2010). This is in contrast to HIV-1, where only 1...


Cervical Cancer Viral Load Undetectable Viral Load Dual Infection Viral Load Measurement 
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Copyright information

© Springer Science+Business Media New York 2015

Authors and Affiliations

  1. 1.Department of Clinical SciencesInstitute of Tropical MedicineAntwerpBelgium
  2. 2.Department of Epidemiology and Social Medicine, Faculty of Medical SciencesUniversity of AntwerpAntwerpBelgium