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Host Genetics and Genomics

  • Living reference work entry
  • First Online:
Encyclopedia of AIDS

  • 223 Accesses

Definition

HIV host genetic research seeks to comprehensively describe human genetic influences on HIV/AIDS. The rationale behind host genetic and genomic analyses, the different study designs, and the proven associations between DNA polymorphism and HIV infection outcomes are discussed in this section.

Heritability of Susceptibility to HIV

Susceptibility to HIV infection varies considerably between individuals, owing in part to the virus itself and to other environmental influences. It has long been known, however, that differences in HIV control are also partially heritable. The strongest evidence comes from in vitro studies of immortalized B lymphocytes from extended families, which demonstrated that more than half of the observed difference in cell susceptibility to HIV-1 is due to the individual genetic background (Loeuillet et al.2008). Heritability is also demonstrated by rare case studies involving related individuals: for example, identical twins concomitantly infected with...

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Authors and Affiliations

  1. School of Life Sciences, Ecole Polytechnique Fédérale de Lausanne, 1015, Lausanne, Vaud, Switzerland

    Jacques Fellay

  2. Institute of Microbiology, University of Lausanne, Rue du Bugnon 48, 1011, Lausanne, Vaud, Switzerland

    Paul McLaren

Authors
  1. Jacques Fellay
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  2. Paul McLaren
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Corresponding author

Correspondence to Jacques Fellay .

Editor information

Editors and Affiliations

  1. Dept. Cell & Molecular Biology, Northwestern University, Feinberg School of Medicine, Chicago, Illinois, USA

    Thomas J. Hope

  2. Office of Graduate and Postdoctoral Studies, University of Miami, Miller School of Medicine, Miami, Florida, USA

    Mario Stevenson

  3. University of California, San Diego Dept. Pathology, La Jolla, California, USA

    Douglas Richman

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Fellay, J., McLaren, P. (2013). Host Genetics and Genomics. In: Hope, T., Stevenson, M., Richman, D. (eds) Encyclopedia of AIDS. Springer, New York, NY. https://doi.org/10.1007/978-1-4614-9610-6_32-1

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  • DOI: https://doi.org/10.1007/978-1-4614-9610-6_32-1

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  • Publisher Name: Springer, New York, NY

  • Online ISBN: 978-1-4614-9610-6

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