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Systems Biology

  • Living reference work entry
  • First Online:
Encyclopedia of AIDS

  • 284 Accesses

Definition

HIV-1 infects CD4+ T cells and completes its replication cycle in approximately 24 h. During this time, infection profoundly perturbs the cellular physiology and makes extensive use of host factors. Cells react to viral invasion by deploying a defense strategy, including general innate immune mediators and specific antiviral factors. At the organism level, the viral-host interaction involves barriers and innate and acquired immunity and results in physiological changes in response to the infectious process. The study of these complex relationships and the tools for large-scale screening of factors involved in cellular and organism responses is part of the field of systems biology.

Systems Biology: Overview

Key elements that define systems biology are (i) the use of high-throughput quantitative measurements (ii) of a model that can be perturbed (iii) in iterative cycles with (iv) integration and modeling of the resulting data. In the context of HIV infection, an ideal systems...

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Authors and Affiliations

  1. Genomic Medicine, J. Craig Venter Institute, 4120 Capricorn Lane, La Jolla, 92037, CA, USA

    Amalio Telenti

  2. School of Life Sciences, École polytechnique fédérale de Lausanne, 1015 Lausanne, Lausanne, Switzerland

    Paul McLaren

Authors
  1. Amalio Telenti
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  2. Paul McLaren
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Correspondence to Amalio Telenti .

Editor information

Editors and Affiliations

  1. Dept. Cell & Molecular Biology, Northwestern University, Feinberg School of Medicine, Chicago, Illinois, USA

    Thomas J. Hope

  2. Office of Graduate and Postdoctoral Studies, University of Miami, Miller School of Medicine, Miami, Florida, USA

    Mario Stevenson

  3. University of California, San Diego Dept. Pathology, La Jolla, California, USA

    Douglas Richman

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Telenti, A., McLaren, P. (2013). Systems Biology. In: Hope, T., Stevenson, M., Richman, D. (eds) Encyclopedia of AIDS. Springer, New York, NY. https://doi.org/10.1007/978-1-4614-9610-6_29-1

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  • DOI: https://doi.org/10.1007/978-1-4614-9610-6_29-1

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  • Online ISBN: 978-1-4614-9610-6

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