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Encyclopedia of AIDS pp 1–7Cite as

Neurotoxic Consequences of Antiretroviral Therapies

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Antiretroviral Therapy (ART) and the Central Nervous System (CNS)

With the introduction of combination antiretroviral therapy (CART), also known as highly active antiretroviral therapy (HAART), for the control of human immunodeficiency virus (HIV) infection, it has been possible to suppress viral quantity in patients’ blood, often to undetectable levels. This intervention has decreased the overall HIV/AIDS disease burden and increased the life span of HIV-infected individuals. However, HIV reservoirs persist in tissue compartments where there is limited access of antiretroviral drugs and/or the presence of long-lived latent HIV reservoirs. Given these circumstances, the complete control of HIV replication and the eradication of HIV have been difficult and infected individuals must continue on treatment regimens indefinitely. Antiretroviral therapies (ARTs) are essential for the effective treatment of HIV infection, but these compounds also have intrinsic toxicity and with long-term...

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Author information

Authors and Affiliations

  1. Department of Neurology, UNC School of Medicine, University of North Carolina, Chapel Hill, NC, 27599, USA

    Rick B. Meeker & Kevin Robertson

  2. Department of Medicine (Neurology), University of Alberta, Edmonton, AB, T6G 2S2, Canada

    Christopher Power

Authors
  1. Rick B. Meeker
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  2. Kevin Robertson
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  3. Christopher Power
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Corresponding author

Correspondence to Rick B. Meeker .

Editor information

Editors and Affiliations

  1. Dept. Cell & Molecular Biology, Northwestern University, Feinberg School of Medicine, Chicago, Illinois, USA

    Thomas J. Hope

  2. Office of Graduate and Postdoctoral Studies, University of Miami, Miller School of Medicine, Miami, Florida, USA

    Mario Stevenson

  3. University of California, San Diego Dept. Pathology, La Jolla, California, USA

    Douglas Richman

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© 2014 Springer Science+Business Media New York

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Meeker, R.B., Robertson, K., Power, C. (2014). Neurotoxic Consequences of Antiretroviral Therapies. In: Hope, T., Stevenson, M., Richman, D. (eds) Encyclopedia of AIDS. Springer, New York, NY. https://doi.org/10.1007/978-1-4614-9610-6_223-1

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  • DOI: https://doi.org/10.1007/978-1-4614-9610-6_223-1

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  • Publisher Name: Springer, New York, NY

  • Online ISBN: 978-1-4614-9610-6

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