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SIV Infection in Mandrills

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  • First Online:
Encyclopedia of AIDS

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Definition

Thousands of years ago, the first simian immunodeficiency virus (SIV) infections occurred in wild African papionine species, specifically among the African mandrills (Mandrillus sphinx, Linnaeus 1758). In contrast to human immunodeficiency virus (HIV) infections, the SIV infection among mandrill populations (SIVmnd) is considered to be nonpathogenic and occurs without clinical symptoms of immune deficiency. Similar to HIV, SIVmnd targets activated CD4 T lymphocytes and leads to high viral loads in the peripheral blood, but the infection is not associated with inflammation and is characterized by low antiviral immune responses. Mandrill SIV infection is thus used as a nonpathogenic model to understand the pathogenesis of AIDS and host protection mechanisms.

Introduction

African mandrills (Mandrillus sphinx) have distinct physical characteristics. Their large size and colorful face (Fig. 1) make them recognizable among all the African monkey populations. While the mandrills...

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Authors and Affiliations

  1. Service d’Immunovirologie, Institute of Emerging Disease and Innovative Therapy, Commissariat à l’Energie Atomique, Fontenay-aux-Roses, France

    Pierre Roques

  2. UMR-E1 Université Paris Sud-XI, Orsay, France

    Pierre Roques

  3. Retrovirology Department, CIRMF, Franceville, Gabon Year 2001-2004

    Pierre Roques

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  1. Pierre Roques
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Correspondence to Pierre Roques .

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Editors and Affiliations

  1. Dept. Cell & Molecular Biology, Northwestern University, Feinberg School of Medicine, Chicago, Illinois, USA

    Thomas J. Hope

  2. Office of Graduate and Postdoctoral Studies, University of Miami, Miller School of Medicine, Miami, Florida, USA

    Mario Stevenson

  3. University of California, San Diego Dept. Pathology, La Jolla, California, USA

    Douglas Richman

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Roques, P. (2014). SIV Infection in Mandrills. In: Hope, T., Stevenson, M., Richman, D. (eds) Encyclopedia of AIDS. Springer, New York, NY. https://doi.org/10.1007/978-1-4614-9610-6_204-1

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  • DOI: https://doi.org/10.1007/978-1-4614-9610-6_204-1

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  • Online ISBN: 978-1-4614-9610-6

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