Encyclopedia of AIDS

Living Edition
| Editors: Thomas J. Hope, Douglas Richman, Mario Stevenson

Epidemiology of AIDS-Defining Malignancies

Living reference work entry
DOI: https://doi.org/10.1007/978-1-4614-9610-6_20-1


AIDS-defining malignancies are a subset of HIV-associated malignancies that include Kaposi sarcoma, some forms of non-Hodgkin lymphoma, and invasive cervical cancer. KS along with PCP are among the first diseases that comprised the original definition of AIDS “in the United States.” Subsequently, non-Hodgkin lymphoma (1985) and invasive cervical cancer were added (CDC 1992). Compared to non-AIDS-defining malignancies, Kaposi sarcoma and non-Hodgkin lymphoma demonstrated the highest incidence in the early AIDS epidemic (see “ History of the AIDS Epidemic”). As shown in Fig. 1, with the introduction of highly active antiretroviral therapy (HAART) in 1996, the incidence patterns of these cancers with the exception of cervical cancer dropped significantly. It is hypothesized that HAART restores immune function and delays progression to AIDS. However, even with the improved clinical outcome, HAART has not eliminated the risk of AIDS-defining malignancies. HIV-positive persons...


Cervical Cancer Immune Reconstitution Inflammatory Syndrome Invasive Cervical Cancer Primary Effusion Lymphoma Multicenter AIDS Cohort Study 
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© Springer Science+Business Media New York 2013

Authors and Affiliations

  1. 1.Division of Epidemiology and Prevention, Institute of Human VirologyUniversity of Maryland School of MedicineBaltimoreUSA