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Encyclopedia of AIDS pp 1–8Cite as

Current Understanding and Persistent Questions About the Pathogenesis and Presentation of Epidemic Kaposi Sarcoma

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Definition

Kaposi sarcoma (KS) is a vascular neoplasm caused by infection with human herpesvirus 8 (HHV-8, also known as Kaposi sarcoma-associated herpesvirus) which may involve the skin, mucous membranes or viscera. Epidemic KS is the form of the disease found among persons with HIV infection; it is the most common malignancy in persons with HIV worldwide.

Introduction

Kaposi sarcoma (KS) remains among the most common cancers seen in persons with human immunodeficiency virus (HIV) infection more than three decades after it was initially described as a key-presenting manifestation of the acquired immunodeficiency syndrome (AIDS) in 1981. While new cases of KS have decreased dramatically in the United States with the widespread availability of combination antiretroviral therapy (cART), the incidence remains threefold higher than prior to the HIV pandemic, and the cancer (Cancers Related to HIV) is the most common in the entire male population of several countries in sub-Saharan Africa....

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Authors and Affiliations

  1. Vaccine and Infectious Disease, Public Health Sciences and Clinical Research Divisions, Departments of Medicine, Epidemiology and Global Health, Fred Hutchinson Cancer Research Center and the University of Washington, 1100 Fairview Avenue North, Mailstop M1-B140, Seattle, WA, USA

    Corey Casper M.D., MPH

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  1. Corey Casper M.D., MPH
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Correspondence to Corey Casper M.D., MPH .

Editor information

Editors and Affiliations

  1. Dept. Cell & Molecular Biology, Northwestern University, Feinberg School of Medicine, Chicago, Illinois, USA

    Thomas J. Hope

  2. Office of Graduate and Postdoctoral Studies, University of Miami, Miller School of Medicine, Miami, Florida, USA

    Mario Stevenson

  3. University of California, San Diego Dept. Pathology, La Jolla, California, USA

    Douglas Richman

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Casper, C. (2013). Current Understanding and Persistent Questions About the Pathogenesis and Presentation of Epidemic Kaposi Sarcoma. In: Hope, T., Stevenson, M., Richman, D. (eds) Encyclopedia of AIDS. Springer, New York, NY. https://doi.org/10.1007/978-1-4614-9610-6_19-1

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  • DOI: https://doi.org/10.1007/978-1-4614-9610-6_19-1

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  • Publisher Name: Springer, New York, NY

  • Online ISBN: 978-1-4614-9610-6

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