Encyclopedia of AIDS

Living Edition
| Editors: Thomas J. Hope, Douglas Richman, Mario Stevenson

HIV-1 Mutational Escape from Host Immunity

Living reference work entry
DOI: https://doi.org/10.1007/978-1-4614-9610-6_189-1

Definition

Within an infected individual, HIV-1 develops specific mutations within its genome that allow it to escape detection by host immune responses. As such, host immunity represents a major selective force driving the evolution and diversification of HIV-1 at the individual and population levels. Here, we highlight HIV-1 mutational escape from adaptive, innate, and vaccine-induced immune responses as highly specific and reproducible processes beginning rapidly following HIV-1 infection. The potential biological implications of immune escape, including viral fitness costs and population-level HIV-1 adaptation to host immunity, are also summarized.

Escape from CD8+ Cytotoxic T Lymphocytes

CD8+ cytotoxic T lymphocytes (CTL) (HIV & SIV, CD8 T Cell Responses) eliminate HIV-infected cells via the recognition of short, virus-derived peptide epitopes that are produced within the infected cell and presented at its surface by the highly polymorphic human leukocyte antigen (HLA) class I...

Keywords

Human Leukocyte Antigen Simian Immunodeficiency Virus Human Leukocyte Antigen Class Human Leukocyte Antigen Allele Immune Escape Mutation 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.
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Copyright information

© Springer Science+Business Media New York 2014

Authors and Affiliations

  1. 1.Faculty of Health SciencesSimon Fraser UniversityBurnabyCanada
  2. 2.British Columbia Centre for Excellence in HIV/AIDSVancouverCanada