HIV-1 Mutational Escape from Host Immunity
Within an infected individual, HIV-1 develops specific mutations within its genome that allow it to escape detection by host immune responses. As such, host immunity represents a major selective force driving the evolution and diversification of HIV-1 at the individual and population levels. Here, we highlight HIV-1 mutational escape from adaptive, innate, and vaccine-induced immune responses as highly specific and reproducible processes beginning rapidly following HIV-1 infection. The potential biological implications of immune escape, including viral fitness costs and population-level HIV-1 adaptation to host immunity, are also summarized.
Escape from CD8+ Cytotoxic T Lymphocytes
CD8+ cytotoxic T lymphocytes (CTL) (HIV & SIV, CD8 T Cell Responses) eliminate HIV-infected cells via the recognition of short, virus-derived peptide epitopes that are produced within the infected cell and presented at its surface by the highly polymorphic human leukocyte antigen (HLA) class I...
KeywordsHuman Leukocyte Antigen Simian Immunodeficiency Virus Human Leukocyte Antigen Class Human Leukocyte Antigen Allele Immune Escape Mutation
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