HIV and SIV, CD4 T-Cell Responses to
Immune responses to infections are a multifaceted interplay between different specialized cell types. These arms of the immune system are broadly divided into innate immunity, which is a rapid first line of defense that has limited specificity toward a particular pathogen, and adaptive immunity, which is delayed but develops with high specificity for pathogens, and once it is established, it has the potential for strong recall responses (immunological memory) (Abbas et al. 2012a). Successful cross talk between innate and adaptive immunity leads to effective immune responses and pathogen clearance. In HIV infection, however, defects in the function of both systems lead to ineffective immune responses that result into lack of viral control and chronic immune activation (Mandell et al. 2010).
CD4 T cells also known as T-helper cells (Th) are cells of the adaptive immune system, and their main role is to orchestrate immune responses by fine tuning the cross talk between the...
KeywordsHuman Leukocyte Antigen Simian Immunodeficiency Virus Human Leukocyte Antigen Class Simian Immunodeficiency Virus Infection Human Leukocyte Antigen Molecule
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