Encyclopedia of AIDS

Living Edition
| Editors: Thomas J. Hope, Douglas Richman, Mario Stevenson

HIV and SIV, CD4 T-Cell Responses to

  • Filippos Porichis
  • Daniel E. Kaufmann
Living reference work entry
DOI: https://doi.org/10.1007/978-1-4614-9610-6_184-1


Immune responses to infections are a multifaceted interplay between different specialized cell types. These arms of the immune system are broadly divided into innate immunity, which is a rapid first line of defense that has limited specificity toward a particular pathogen, and adaptive immunity, which is delayed but develops with high specificity for pathogens, and once it is established, it has the potential for strong recall responses (immunological memory) (Abbas et al. 2012a). Successful cross talk between innate and adaptive immunity leads to effective immune responses and pathogen clearance. In HIV infection, however, defects in the function of both systems lead to ineffective immune responses that result into lack of viral control and chronic immune activation (Mandell et al. 2010).

CD4 T cells also known as T-helper cells (Th) are cells of the adaptive immune system, and their main role is to orchestrate immune responses by fine tuning the cross talk between the...


Human Leukocyte Antigen Simian Immunodeficiency Virus Human Leukocyte Antigen Class Simian Immunodeficiency Virus Infection Human Leukocyte Antigen Molecule 
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Copyright information

© Springer Science+Business Media New York 2014

Authors and Affiliations

  1. 1.The Ragon Institute of MGH, MIT and HarvardCambridgeUSA
  2. 2.Centre de Recherche du Centre Hospitalier de l’Université de Montréal (CRCHUM) and University of MontrealMontréalCanada