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Central Memory CD4 T Cells

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  • First Online:
Encyclopedia of AIDS

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Definition

Memory CD4 T cells can be divided into central memory (TCM) and effector memory (TEM) subsets, which are endowed with different homing and proliferative capacities as well as distinct effector functions (Sallusto et al. 1999). TCM cells can directly home to secondary lymphoid organs and express the lymphoid homing molecules CD62L (L-selectin) and CCR7 (chemokine receptor 7). In contrast, TEM cells home to tertiary sites and tissues and have direct effector functions upon stimulation, including secretion of inflammatory cytokines such as interferon gamma (IFN-γ) and tumor necrosis factor (TNF). Thus, TCM cells define a lymphoid homing subset without immediate effector function, whereas TEM cells are defined as a subpopulation that localize to tissues, with rapidly induced effector function and less proliferative potential. A dominant theory is that TCM represent a precursor to TEM as TCM have greater proliferative potential, are longer lived, and can generate TEMand T...

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References

  • Ahmed R, Bevan MJ, Reiner SL, Fearon DT. The precursors of memory: models and controversies. Nat Rev Immunol. 2009;9:662–8.

    Article  PubMed  CAS  Google Scholar 

  • Bacchus C, Cheret A, Avettand-Fenoel V, Nembot G, Melard A, Blanc C, Lascoux-Combe C, Slama L, Allegre T, Allavena C, Yazdanpanah Y, Duvivier C, Katlama C, Goujard C, Seksik BC, Leplatois A, Molina JM, Meyer L, Autran B, Rouzioux C, O. A. S. Group. A single HIV-1 cluster and a skewed immune homeostasis drive the early spread of HIV among resting CD4+ cell subsets within one month post-infection. PLoS One. 2003;8:e64219.

    Article  Google Scholar 

  • Baldauf HM, Pan X, Erikson E, Schmidt S, Daddacha W, Burggraf M, Schenkova K, Ambiel I, Wabnitz G, Gramberg T, Panitz S, Flory E, Landau NR, Sertel S, Rutsch F, Lasitschka F, Kim B, Konig R, Fackler OT, Keppler OT. SAMHD1 restricts HIV-1 infection in resting CD4(+) T cells. Nat Med. 2012;18:1682–7.

    Article  PubMed  CAS  Google Scholar 

  • Bosque A, Planelles V. Induction of HIV-1 latency and reactivation in primary memory CD4+ T cells. Blood. 2009;113:58–65.

    Article  PubMed  CAS  PubMed Central  Google Scholar 

  • Bosque A, Famiglietti M, Weyrich AS, Goulston C, Planelles V. Homeostatic proliferation fails to efficiently reactivate HIV-1 latently infected central memory CD4+ T cells. PLoS Pathog. 2011;7:e1002288.

    Article  PubMed  CAS  PubMed Central  Google Scholar 

  • Brenchley JM, Hill BJ, Ambrozak DR, Price DA, Guenaga FJ, Casazza JP, Kuruppu J, Yazdani J, Migueles SA, Connors M, Roederer M, Douek DC, Koup RA. T-cell subsets that harbor human immunodeficiency virus (HIV) in vivo: implications for HIV pathogenesis. J Virol. 2004;78:1160–8.

    Article  PubMed  CAS  PubMed Central  Google Scholar 

  • Buzon MJ, Sun H, Li C, Shaw A, Seiss K, Ouyang Z, Martin-Gayo E, Leng J, Henrich TJ, Li JZ, Pereyra F, Zurakowski R, Walker BD, Rosenberg ES, Yu XG, Lichterfeld M. HIV-1 persistence in CD4(+) T cells with stem cell-like properties. Nat Med. 2014;20:139–42.

    Article  PubMed  CAS  PubMed Central  Google Scholar 

  • Chomont N, El-Far M, Ancuta P, Trautmann L, Procopio FA, Yassine-Diab B, Boucher G, Boulassel MR, Ghattas G, Brenchley JM, Schacker TW, Hill BJ, Douek DC, Routy JP, Haddad EK, Sekaly RP. HIV reservoir size and persistence are driven by T cell survival and homeostatic proliferation. Nat Med. 2009;15:893–900.

    Article  PubMed  CAS  PubMed Central  Google Scholar 

  • Descours B, Cribier A, Chable-Bessia C, Ayinde D, Rice G, Crow Y, Yatim A, Schwartz O, Laguette N, Benkirane M. SAMHD1 restricts HIV-1 reverse transcription in quiescent CD4(+) T-cells. Retrovirology. 2012a;9:87.

    Article  PubMed  CAS  PubMed Central  Google Scholar 

  • Descours B, Avettand-Fenoel V, Blanc C, Samri A, Melard A, Supervie V, Theodorou I, Carcelain G, Rouzioux C, Autran B, A. A. C. S. Group. Immune responses driven by protective human leukocyte antigen alleles from long-term nonprogressors are associated with low HIV reservoir in central memory CD4 T cells. Clin Infect Dis. 2012b;54:1495–503.

    Article  PubMed  CAS  Google Scholar 

  • Flynn JK, Paukovics G, Cashin K, Borm K, Ellett A, Roche M, Jakobsen MR, Churchill MJ, Gorry PR. Quantifying susceptibility of CD4+ stem memory T-cells to infection by laboratory adapted and clinical HIV-1 strains. Viruses. 2014;6:709–26.

    Article  PubMed  PubMed Central  Google Scholar 

  • Gattinoni L, Lugli E, Ji Y, Pos Z, Paulos CM, Quigley MF, Almeida JR, Gostick E, Yu Z, Carpenito C, Wang E, Douek DC, Price DA, June CH, Marincola FM, Roederer M, Restifo NP. A human memory T cell subset with stem cell-like properties. Nat Med. 2011;17:1290–7.

    Article  PubMed  CAS  PubMed Central  Google Scholar 

  • Groot F, van Capel TM, Schuitemaker J, Berkhout B, de Jong EC. Differential susceptibility of naive, central memory and effector memory T cells to dendritic cell-mediated HIV-1 transmission. Retrovirology. 2006;3:52.

    Article  PubMed  PubMed Central  Google Scholar 

  • Kaech SM, Wherry EJ, Ahmed R. Effector and memory T-cell differentiation: implications for vaccine development. Nat Rev Immunol. 2002;2:251–62.

    Article  PubMed  CAS  Google Scholar 

  • Karris MY, Kao YT, Patel D, Dawson M, Woods SP, Vaida F, Spina C, Richman D, Little S, Smith DM. Predictors of virologic response in persons who start antiretroviral therapy during recent HIV infection. AIDS. 2014;28:841–9.

    Article  PubMed  CAS  PubMed Central  Google Scholar 

  • Lassen KG, Hebbeler AM, Bhattacharyya D, Lobritz MA, Greene WC. A flexible model of HIV-1 latency permitting evaluation of many primary CD4 T-cell reservoirs. PLoS One. 2012;7:e30176.

    Article  PubMed  CAS  PubMed Central  Google Scholar 

  • McGary CS, Cervasi B, Chahroudi A, Micci L, Taffee J, Meeker T, Silvestri G, Davenport MP, Paiardini M. Increased stability and limited proliferation of CD4+ central memory T cells differentiate non-progressive SIV-infection of sooty mangabeys from progressive SIV-infection of rhesus macaques. J Virol. 2014;88:4533–42.

    Article  PubMed  PubMed Central  Google Scholar 

  • Okoye A, Meier-Schellersheim M, Brenchley JM, Hagen SI, Walker JM, Rohankhedkar M, Lum R, Edgar JB, Planer SL, Legasse A, Sylwester AW, Piatak Jr M, Lifson JD, Maino VC, Sodora DL, Douek DC, Axthelm MK, Grossman Z, Picker LJ. Progressive CD4+ central memory T cell decline results in CD4+ effector memory insufficiency and overt disease in chronic SIV infection. J Exp Med. 2007;204:2171–85.

    Article  PubMed  CAS  PubMed Central  Google Scholar 

  • Perreau M, Savoye AL, De Crignis E, Corpataux JM, Cubas R, Haddad EK, De Leval L, Graziosi C, Pantaleo G. Follicular helper T cells serve as the major CD4 T cell compartment for HIV-1 infection, replication, and production. J Exp Med. 2013;210:143–56.

    Article  PubMed  CAS  PubMed Central  Google Scholar 

  • Saez-Cirion A, Bacchus C, Hocqueloux L, Avettand-Fenoel V, Girault I, Lecuroux C, Potard V, Versmisse P, Melard A, Prazuck T, Descours B, Guergnon J, Viard JP, Boufassa F, Lambotte O, Goujard C, Meyer L, Costagliola D, Venet A, Pancino G, Autran B, Rouzioux C, A. V. S. Group. Post-treatment HIV-1 controllers with a long-term virological remission after the interruption of early initiated antiretroviral therapy ANRS VISCONTI study. PLoS Pathog. 2013;9:e1003211.

    Article  PubMed  CAS  PubMed Central  Google Scholar 

  • Sallusto F, Lenig D, Forster R, Lipp M, Lanzavecchia A. Two subsets of memory T lymphocytes with distinct homing potentials and effector functions. Nature. 1999;401:708–12.

    Article  PubMed  CAS  Google Scholar 

  • Sieg SF, Rodriguez B, Asaad R, Jiang W, Bazdar DA, Lederman MM. Peripheral S-phase T cells in HIV disease have a central memory phenotype and rarely have evidence of recent T cell receptor engagement. J Infect Dis. 2005;192:62–70.

    Article  PubMed  CAS  Google Scholar 

  • van Grevenynghe J, Procopio FA, He Z, Chomont N, Riou C, Zhang Y, Gimmig S, Boucher G, Wilkinson P, Shi Y, Yassine-Diab B, Said EA, Trautmann L, El Far M, Balderas RS, Boulassel MR, Routy JP, Haddad EK, Sekaly RP. Transcription factor FOXO3a controls the persistence of memory CD4(+) T cells during HIV infection. Nat Med. 2008;14:266–74.

    Article  PubMed  Google Scholar 

  • Yang X, Jiao YM, Wang R, Ji YX, Zhang HW, Zhang YH, Chen DX, Zhang T, Wu H. High CCR5 density on central memory CD4+ T cells in acute HIV-1 infection is mostly associated with rapid disease progression. PLoS One. 2012;7:e49526.

    Article  PubMed  CAS  PubMed Central  Google Scholar 

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Authors and Affiliations

  1. Vaccine and Gene Therapy Institute of Florida, 9801 S.W. Discovery Way, Port St Lucie, FL, 34987, USA

    Shannon Murray, Rémi Fromentin & Nicolas Chomont

Authors
  1. Shannon Murray
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  2. RĂ©mi Fromentin
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  3. Nicolas Chomont
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Correspondence to Shannon Murray .

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Editors and Affiliations

  1. Dept. Cell & Molecular Biology, Northwestern University, Feinberg School of Medicine, Chicago, Illinois, USA

    Thomas J. Hope

  2. Office of Graduate and Postdoctoral Studies, University of Miami, Miller School of Medicine, Miami, Florida, USA

    Mario Stevenson

  3. University of California, San Diego Dept. Pathology, La Jolla, California, USA

    Douglas Richman

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Murray, S., Fromentin, R., Chomont, N. (2014). Central Memory CD4 T Cells. In: Hope, T., Stevenson, M., Richman, D. (eds) Encyclopedia of AIDS. Springer, New York, NY. https://doi.org/10.1007/978-1-4614-9610-6_177-1

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  • DOI: https://doi.org/10.1007/978-1-4614-9610-6_177-1

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  • Online ISBN: 978-1-4614-9610-6

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