Definition
Preexposure prophylaxis (PrEP) is any medical or public health procedure used before exposure to the disease-causing agent; its purpose is to prevent rather than treat or cure a disease. The use of antiretroviral agents as PrEP is an experimental approach to HIV prevention that has recently been shown to successfully prevent the sexual transmission of HIV in several clinical trials. The challenge now is to determine how to translate these promising findings into a public health impact. Making the leap from clinical trials to real-world implementation of PrEP for HIV prevention presents a particular challenge because it requires multiple biomedical, behavioral, and social interventions in combination to maximize their synergy as appropriate for each unique epidemic setting. In real-world settings, particular effort will be needed to ensure high adherence, which has been shown to be challenging even in controlled clinical trial settings. Despite the numerous challenges in...
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Abdool Karim, S.S., Baxter, C. (2014). HIV-1 Preexposure Prophylaxis. In: Hope, T., Stevenson, M., Richman, D. (eds) Encyclopedia of AIDS. Springer, New York, NY. https://doi.org/10.1007/978-1-4614-9610-6_152-1
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DOI: https://doi.org/10.1007/978-1-4614-9610-6_152-1
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