Preventing HIV-1 Transmission Through Vaccine-Induced Immune Responses
According to UNAIDS, globally 35.0 million people were living with HIV at the end of 2013. Sub-Saharan Africa remains most severely affected, accounting for 71 % of the people living with HIV-1 worldwide. The number of people newly infected or who died from AIDS-related causes declined worldwide. Despite genuine, although unequal and fragile, successes in prevention programs attributed to strengthening and scaling up prevention strategies and antiretroviral treatment, the development of a preventive HIV-1 vaccine as part of a comprehensive prevention package remains among the best hopes for controlling the HIV-1 pandemic. By inducing appropriate immune responses directed against a specific pathogen, vaccines remain the most powerful public health tool to prevent infectious diseases. They may either prevent infection by the pathogen or the development of the disease due to this pathogen.
Goals of an HIV-1 Vaccine
The most promising approach to lead an HIV-1 vaccine to...
KeywordsVaccine Efficacy Inject Drug User Vaccine Regimen Boost Regimen Gp120 Vaccine
The views expressed are those of the authors and should not be construed to represent the positions of the U.S. Army or the Department of Defense.