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Dendritic Cell Interactions with HIV-1 Envelope Glycoprotein: Implications for Preventing Transmission

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Encyclopedia of AIDS

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Definition

Dendritic cells (DCs) are critical sentinels of the immune system and potent antigen-presenting cells. They patrol peripheral tissues including the blood, skin, and mucosal surfaces, poised to sense and respond to incoming microbes. Upon encountering a microbe, DCs engulf it and are triggered to migrate to the lymph nodes. Along the way they degrade the microbe and undergo a process of maturation that includes upregulation of molecules associated with antigen presentation. In the lymph node, DCs present their antigen on major histocompatibility complex (MHC) class I and II molecules to T cells and thus activate an adaptive immune response specific to the microbe. DCs can be one of the first cell types to encounter HIV. The virus has evolved to exploit the natural function of DCs, which includes avoiding degradation in order to gain access to its primary target – the CD4+T cells. DCs are therefore a key target to investigate for strategies to prevent HIV transmission. In...

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Authors and Affiliations

  1. Centre for Virus Research, Westmead Millennium Institute, Sydney, Australia

    Kerrie J. Sandgren

  2. Department of Medicine, Clinical Immunology and Allergy Unit, Karolinska Institutet and University Hospital, Stockholm, Sweden

    Kerrie J. Sandgren, Frank Liang, Anna Smed-Sörensen & Karin Loré

Authors
  1. Kerrie J. Sandgren
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  2. Frank Liang
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  3. Anna Smed-Sörensen
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  4. Karin Loré
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Corresponding author

Correspondence to Kerrie J. Sandgren .

Editor information

Editors and Affiliations

  1. Dept. Cell & Molecular Biology, Northwestern University, Feinberg School of Medicine, Chicago, Illinois, USA

    Thomas J. Hope

  2. Office of Graduate and Postdoctoral Studies, University of Miami, Miller School of Medicine, Miami, Florida, USA

    Mario Stevenson

  3. University of California, San Diego Dept. Pathology, La Jolla, California, USA

    Douglas Richman

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Sandgren, K.J., Liang, F., Smed-Sörensen, A., Loré, K. (2014). Dendritic Cell Interactions with HIV-1 Envelope Glycoprotein: Implications for Preventing Transmission. In: Hope, T., Stevenson, M., Richman, D. (eds) Encyclopedia of AIDS. Springer, New York, NY. https://doi.org/10.1007/978-1-4614-9610-6_133-1

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  • DOI: https://doi.org/10.1007/978-1-4614-9610-6_133-1

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  • Online ISBN: 978-1-4614-9610-6

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