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Presentation and Pathogenesis of B-Cell Lymphoid Cancers Associated with HIV Infection

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Encyclopedia of AIDS

Definition

Lymphoid neoplastic manifestations of HIV infection include a spectrum of diseases each with specific clinical, epidemiologic, and biological features. This chapter reviews the important lymphoid tumors occurring in HIV infection with an emphasis on the important distinctions relevant to presentation, diagnosis, and clinical management of the various entities.

Introduction and Overview

During the late 1970s and early 1980s, marked changes in the typical occurrence and clinical behavior of aggressive B-cell lymphomas were among the initial manifestation of the new epidemic disease that ultimately became known as the acquired immunodeficiency syndrome, AIDS. The original Centers for Disease Control and Prevention case definition expanding the definition in 1982 of AIDS to include lymphoma specified that a patient with HIV and an aggressive B-cell lymphoma would carry an AIDS diagnosis. Several years later, this definition was expanded to include intermediate-grade B-cell...

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References

  • Abayomi EA, Somers A, et al. Impact of the HIV epidemic and anti-retroviral treatment policy on lymphoma incidence and subtypes seen in the Western Cape of South Africa, 2002–2009: preliminary findings of the Tygerberg Lymphoma Study Group. Transfus Apher Sci. 2011;44(2):161–6.

    Article  PubMed Central  CAS  PubMed  Google Scholar 

  • Alizadeh AA, Eisen MB, et al. Distinct types of diffuse large B-cell lymphoma identified by gene expression profiling. Nature. 2000;403(6769):503–11.

    Article  CAS  PubMed  Google Scholar 

  • Besson C, Goubar A, et al. Changes in AIDS-related lymphoma since the era of highly active antiretroviral therapy. Blood. 2001;98(8):2339–44.

    Article  CAS  PubMed  Google Scholar 

  • Biggar RJ, Jaffe ES, et al. Hodgkin lymphoma and immunodeficiency in persons with HIV/AIDS. Blood. 2006;108(12):3786–91.

    Article  PubMed Central  CAS  PubMed  Google Scholar 

  • Breen E, Fatahi S, et al. Elevated serum soluble CD30 precedes the development of AIDS-associated non-Hodgkin’s B cell lymphoma. Tumour Biol. 2006;27(4):187–94.

    Article  CAS  PubMed  Google Scholar 

  • Castillo JJ, Beltran BE, et al. The Hans algorithm is not prognostic in patients with diffuse large B-cell lymphoma treated with R-CHOP. Leuk Res. 2012;36(4):413–7.

    Article  PubMed  Google Scholar 

  • Chadburn A, Chiu A, et al. Immunophenotypic analysis of AIDS-related diffuse large B-cell lymphoma and clinical implications in patients from AIDS malignancies consortium clinical trials 010 and 034. J Clin Oncol. 2009;27(30):5039–48. JCO.2008.2020.5450.

    Article  PubMed Central  PubMed  Google Scholar 

  • Dunleavy K, Wilson WH. How I treat HIV-associated lymphoma. Blood. 2012;119(14):3245–55.

    Article  PubMed Central  CAS  PubMed  Google Scholar 

  • Dunleavy K, Little RF, et al. The role of tumor histogenesis, FDG-PET, and short course EPOCH with dose-dense rituximab (SC-EPOCH-RR) in HIV-associated diffuse large B-cell lymphoma. Blood. 2010;115(15):3017–24.

    Article  PubMed Central  CAS  PubMed  Google Scholar 

  • Fan W, Bubman D, et al. Distinct subsets of primary effusion lymphoma can be identified based on their cellular gene expression profile and viral association. J Virol. 2005;79(2):1244–51.

    Article  PubMed Central  CAS  PubMed  Google Scholar 

  • Lindqvist M, van Lunzen J, et al. Expansion of HIV-specific T follicular helper cells in chronic HIV infection. J Clin Invest. 2012;122(9):3271–80.

    Article  PubMed Central  CAS  PubMed  Google Scholar 

  • Little RF, Pittaluga S, et al. Highly effective treatment of acquired immunodeficiency syndrome-related lymphoma with dose-adjusted EPOCH: impact of antiretroviral therapy suspension and tumor biology. Blood. 2003;101(12):4653–9.

    Article  CAS  PubMed  Google Scholar 

  • Montoto S, Shaw K, et al. HIV status does not influence outcome in patients with classical Hodgkin lymphoma treated with chemotherapy using doxorubicin, bleomycin, vinblastine, and dacarbazine in the highly active antiretroviral therapy era. J Clin Oncol. 2012;30(33):4111–6.

    Article  PubMed  Google Scholar 

  • Raez L, Cabral L, et al. Treatment of AIDS-related primary central nervous system lymphoma with zidovudine, ganciclovir, and interleukin 2. AIDS Res Hum Retroviruses. 1999;15(8):713–9.

    Article  CAS  PubMed  Google Scholar 

  • Rosenwald A, Wright G, et al. The use of molecular profiling to predict survival after chemotherapy for diffuse large-B-cell lymphoma. N Engl J Med. 2002;346(25):1937–47.

    Article  PubMed  Google Scholar 

  • Sasakawa A, Hirase C, et al. Interleukin-8 in the pathogenesis of primary central nervous system lymphoma in association with HIV infection. Hematology. 2012;17(3):144–50.

    Article  CAS  PubMed  Google Scholar 

  • Schmitz R, Young RM, et al. Burkitt lymphoma pathogenesis and therapeutic targets from structural and functional genomics. Nature. 2012;490(7418):116–20. Advance online publication.

    Article  PubMed Central  CAS  PubMed  Google Scholar 

  • Shiels MS, Engels EA. Increased risk of histologically defined cancer subtypes in human immunodeficiency virus-infected individuals: clues for possible immunosuppression-related or infectious etiology. Cancer. 2012;118(19):4869–76.

    Article  PubMed Central  PubMed  Google Scholar 

  • Swerdlow SH, Campo E, et al. WHO classification of tumors of Haematopoietic and lymphoid tissues. Lyon: World Health Organization; 2008.

    Google Scholar 

  • Uldrick TS, Polizzotto MN, et al. High-dose zidovudine plus valganciclovir for Kaposi sarcoma herpesvirus-associated multicentric Castleman disease: a pilot study of virus-activated cytotoxic therapy. Blood. 2011;117(26):6977–86.

    Article  PubMed Central  CAS  PubMed  Google Scholar 

  • Wilson WH, Hernandez-Ilizaliturri FJ, et al. Novel disease targets and management approaches for diffuse large B-cell lymphoma. Leuk Lymphoma. 2010;51(S1):1–10.

    Article  PubMed  Google Scholar 

  • Yang Y, Shaffer III AL, et al. Exploiting synthetic lethality for the therapy of ABC diffuse large B cell lymphoma. Cancer Cell. 2012;21(6):723–37.

    Article  PubMed Central  CAS  PubMed  Google Scholar 

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Correspondence to Richard F. Little .

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Little, R.F., Pittaluga, S., Dunleavy, K. (2013). Presentation and Pathogenesis of B-Cell Lymphoid Cancers Associated with HIV Infection. In: Hope, T., Stevenson, M., Richman, D. (eds) Encyclopedia of AIDS. Springer, New York, NY. https://doi.org/10.1007/978-1-4614-9610-6_13-1

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  • DOI: https://doi.org/10.1007/978-1-4614-9610-6_13-1

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  • Online ISBN: 978-1-4614-9610-6

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