Definition
Kaposi’s sarcoma (KS) (Overview: Aids-Related and Non-aids-Related Cancers; Cancers Related to HIV) is a multifocal angiogenic neoplasm whose development requires systemic infection with a human herpesvirus, known as human herpesvirus-8 (HHV-8) or the KS-associated herpesvirus (KSHV) (Kaposi’s Sarcoma-Associated Herpesvirus). KSHV infection is required for the development of this neoplasm, but KS occurs in only a fraction of KSHV-infected individuals. Although KS lesions may arise in the absence of overt immunodeficiency, defects in endogenous viral control mechanisms increase the likelihood that KS will develop (Epidemiology of AIDS-Related Malignancies). KS is thus more frequently observed among individuals with underlying conditions, such as HIV infection, which impair antiviral immune responses, and is considered an AIDS-defining condition when it occurs in an HIV-infected person. In formulating a management strategy for KS in HIV-infected individuals, two main aspects...
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Krown, S.E. (2013). Management of AIDS-Related Kaposi’s Sarcoma. In: Hope, T., Stevenson, M., Richman, D. (eds) Encyclopedia of AIDS. Springer, New York, NY. https://doi.org/10.1007/978-1-4614-9610-6_12-1
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DOI: https://doi.org/10.1007/978-1-4614-9610-6_12-1
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