Introduction
CD27 is located at 12p13 and encodes CD27, a member of the tumor necrosis factor family that is alternately known as tumor necrosis factor receptor superfamily, member 7. The 55 kDa transmembrane molecule is constitutively expressed on the surface of naïve and memory CD4+ and CD8+ T cells and is downregulated by a proportion of effector T cells (Sugita et al. 1992; Hintzen et al. 1994). It is also found on CD56bright natural killer (NK) cells and at low levels on CD56dim NK cells (Bullock 2017; Buchan et al. 2018). CD27 is well-known as a marker for memory, but not naïve, B cells, yet its function in B lymphocytes remains poorly understood. CD27 typically resides at the cellular membrane as a disulfide-linked homodimeric receptor, but membrane-bound monomeric CD27 can also exist (Buchan et al. 2018). A smaller soluble 32 kDa form is known to be produced from the full-length, mature peptide (Hintzen et al. 1994). The role of soluble CD27 has not been established. CD70...
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References
Alkhairy OK, Perez-Becker R, Driessen GJ, et al. Novel mutations in TNFRSF7/CD27: clinical, immunologic, and genetic characterization of human CD27 deficiency. J Allergy Clin Immunol. 2015;136:703–12.e10.
Borst J, Hendriks J, Xiao Y. CD27 and CD70 in T cell and B cell activation. Curr Opin Immunol. 2005;17:275–81.
Buchan SL, Rogel A, Al-Shamkhani A. The immunobiology of CD27 and OX40 and their potential as targets for cancer immunotherapy. Blood. 2018;131:39–48.
Bullock TNJ. Stimulating CD27 to quantitatively and qualitatively shape adaptive immunity to cancer. Curr Opin Immunol. 2017;45:82–8.
Denoeud J, Moser M. Role of CD27/CD70 pathway of activation in immunity and tolerance. J Leukoc Biol. 2011;89:195–203.
Grant EJ, Nüssing S, Sant S, Clemens EB, Kedzierska K. The role of CD27 in anti-viral T-cell immunity. Curr Opin Virol. 2017;22:77–88.
Han BK, Olsen NJ, Bottaro A. The CD27–CD70 pathway and pathogenesis of autoimmune disease. Semin Arthritis Rheum. 2016;45:496–501.
Hintzen RQ, de Jong R, Lens SMA, van Lier RW. CD27: marker and mediator of T-cell activation? Immunol Today. 1994;15:307–11.
Nolte MA, Van Olffen RW, Van Gisbergen KPJM, Van Lier RAW. Timing and tuning of CD27–CD70 interactions: the impact of signal strength in setting the balance between adaptive responses and immunopathology. Immunol Rev. 2009;229:216–31.
Salzer E, Daschkey S, Choo S, et al. Combined immunodeficiency with life-threatening EBV-associated lymphoproliferative disorder in patients lacking functional CD27. Haematologica. 2013;98:473.
Sugita K, Hirose T, Rothstein DM, Donahue C, Schlossman SF, Morimoto C. CD27, a member of the nerve growth factor receptor family, is preferentially expressed on CD45RA+ CD4 T cell clones and involved in distinct immunoregulatory functions. J Immunol. 1992;149:3208.
van Montfrans JM, Hoepelman AIM, Otto S, et al. CD27 deficiency is associated with combined immunodeficiency and persistent symptomatic EBV viremia. J Allergy Clin Immunol. 2012;129:787–93.e6.
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Chinn, I.K. (2020). CD27 Deficiency. In: MacKay, I., Rose, N. (eds) Encyclopedia of Medical Immunology. Springer, New York, NY. https://doi.org/10.1007/978-1-4614-9209-2_206-1
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DOI: https://doi.org/10.1007/978-1-4614-9209-2_206-1
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