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CARD14-Mediated Psoriasis and Pityriasis Rubra Piliaris (PRP)

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Encyclopedia of Medical Immunology

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Synonyms

CARD14: Caspase recruitment domain-containing protein 14

CARMA2: CARD-containing membrane-associated guanylate kinase (MAGUK) protein 2

Bimp2: bcl10-interacting maguk protein 2

CAMPS: CARD14 mediated psoriasis

PRP: Pityriasis rubra pilaris

Definition

CARD14 is an important cutaneous scaffold protein. Gain of function mutations in CARD14 lead to enhanced or sustained NF-kB activation, and up-regulation of its target genes which include pro-inflammatory cytokines. The consequence of these and downstream transcriptional alterations are seen clinically as psoriasis or pityriasis rubra pilaris (PRP).

Introduction and Background

Discovery of Disease-Causing CARD14 Mutations

Psoriasis susceptibility locus 2 (PSORS2) was mapped in 1994 to human chromosomal region 17q25-qter in a single large European family (PS1) (Tomfohrde et al. 1994). Affected members had plaque psoriasis and 30% also developed psoriatic arthritis. A second genome-wide linkage scan in a five-generation Taiwanese...

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References

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Author information

Author notes

  1. Michelle A. Lowes and Anne M. Bowcock equally contributed to this work.

Authors and Affiliations

  1. The Rockefeller University, New York, NY, USA

    Michelle A. Lowes

  2. Icahn School of Medicine at Mount Sinai, New York, NY, USA

    Anne M. Bowcock

Authors
  1. Michelle A. Lowes
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  2. Anne M. Bowcock
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Corresponding authors

Correspondence to Michelle A. Lowes or Anne M. Bowcock .

Editor information

Editors and Affiliations

  1. Molecular Biology, Monash University Dept. Biochemistry &, Clayton, Victoria, Australia

    Ian MacKay

  2. Autoimmune Disease Research Center, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA

    Noel R. Rose

Section Editor information

  1. NIAID, Translational Autoinflammatory Disease Studies, National Institutes of Health Clinical Center, Bethesda, Maryland, USA

    Raphaela T. Goldbach-Mansky

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Lowes, M.A., Bowcock, A.M. (2018). CARD14-Mediated Psoriasis and Pityriasis Rubra Piliaris (PRP). In: MacKay, I., Rose, N. (eds) Encyclopedia of Medical Immunology. Springer, New York, NY. https://doi.org/10.1007/978-1-4614-9209-2_122-1

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  • DOI: https://doi.org/10.1007/978-1-4614-9209-2_122-1

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  • Publisher Name: Springer, New York, NY

  • Print ISBN: 978-1-4614-9209-2

  • Online ISBN: 978-1-4614-9209-2

  • eBook Packages: Springer Reference MedicineReference Module Medicine

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