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Encyclopedia of Medical Immunology pp 1–4Cite as

Caspase Recruitment Domain 11, CARD11

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Synonyms

OMIM 697210; OMIM #607210; HGNC 16393; Caspase recruitment domain family member 11

Definition

Membrane-associated guanylate kinase.

Introduction/Background

The caspase recruitment domain (CARD) is a protein-binding module that mediates the assembly of CARD-containing proteins into apoptosis and nuclear factor kappa-light chain-enhancer of activated B cells (NF-kB) pro-inflammatory signaling complexes. Caspase recruitment and oligomerization mediated by adaptor proteins constitute one of multiple mechanisms that help coordinate immunity development, activation, cell migration, and apoptosis.

Function

The CARD domain of CARD11 associates specifically with the CARD domain of B cell lymphoma/leukemia 10 (BCL10), a signaling protein that activates NF-kB through the inhibitor of kappa B (IκB) kinase (IKK) complex. Another related paracaspase protein, mucosa-associated lymphoid tissue lymphoma-translocation gene 1 (MALT1), interacts with CARD11 and BCL10 to form the tripartite...

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References

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Author information

Authors and Affiliations

  1. Professor of Medicine and Pediatrics, Indiana University School of Medicine, Immunohematology and Transplantation, Indianapolis, IN, USA

    Robert P. Nelson Jr.

Authors
  1. Robert P. Nelson Jr.
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Corresponding author

Correspondence to Robert P. Nelson Jr. .

Editor information

Editors and Affiliations

  1. Molecular Biology, Monash University Dept. Biochemistry &, Clayton, VIC, Australia

    Ian MacKay

  2. Autoimmune Disease Research Center, Johns Hopkins University School of Medicine, Baltimore, MD, USA

    Noel R. Rose

Section Editor information

  1. University of Washington and Seattle Children's Hospital, Seattle, USA

    M Teresa de la Morena

  2. Hematology and Oncology, Indiana University, Indianapolis, USA

    Robert P. Nelson

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Nelson, R.P. (2019). Caspase Recruitment Domain 11, CARD11. In: MacKay, I., Rose, N. (eds) Encyclopedia of Medical Immunology. Springer, New York, NY. https://doi.org/10.1007/978-1-4614-9209-2_108-1

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  • DOI: https://doi.org/10.1007/978-1-4614-9209-2_108-1

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  • Publisher Name: Springer, New York, NY

  • Print ISBN: 978-1-4614-9209-2

  • Online ISBN: 978-1-4614-9209-2

  • eBook Packages: Springer Reference MedicineReference Module Medicine

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