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Genetic Regulation of IgE

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  • First Online:
Encyclopedia of Medical Immunology

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Definition

Genetic regulation of IgE: influence of genes and variations of genes (polymorphisms) on the propensity of producing immunoglobulin E (IgE) in humans.

Introduction

Atopic diseases such as atopic dermatitis, allergic asthma, allergic rhinitis, and food allergy are based on genetic determinants with a reported heritability of up to 80 % (Cookson and Moffatt 2000; Vercelli 2008; Gould and Sutton 2008). Atopic diseases are typical complex, polygenic traits, which are believed to be influenced by the environment, gene–gene interactions, and multiple genetic variants. A large number of candidate gene studies have been conducted for atopic diseases, results of which were often inconsistent. The candidate genes that could be determined confer either a disease-specific risk or appear to be important for the atopic state rather than for a specific atopic disease. The exclusive assignment of association to either a disease-specific risk or the atopic state very much confines the...

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Author information

Authors and Affiliations

  1. Division of Pediatric Pulmonology, Allergy and Endocrinology, Department of Pediatrics and Juvenile Medicine, Medical University of Vienna, Währinger Gürtel 18-20, 1090, Vienna, Austria

    Zsolt Szépfalusi

  2. Department of Pediatrics and Adolescent Medicine, Medical University of Vienna, Vienna, Austria

    Thomas Eiwegger

Authors
  1. Zsolt Szépfalusi
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  2. Thomas Eiwegger
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Corresponding author

Correspondence to Zsolt Szépfalusi .

Editor information

Editors and Affiliations

  1. Department of Biochemistry and Molecular Biology, Monash University, Clayton, Victoria, Australia

    Ian R. Mackay

  2. Center for Autoimmune Disease Research, Department of Molecular Microbiology and Immunology, Department of Pathology, Johns Hopkins University, Baltimore, MD, USA

    Noel R. Rose

  3. Division of Allergy and Immunology, Department of Internal Medicine, University of South Florida Morsani College of Medicine, James A. Haley Veterans' Hospital, Tampa, FL, USA

    Dennis K. Ledford

  4. Division of Allergy and Immunology, Department of Internal Medicine, University of South Florida Morsani College of Medicine, James A. Haley Veterans' Hospital, Tampa, FL, USA

    Richard F. Lockey

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© 2014 Springer-Verlag Berlin Heidelberg

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Szépfalusi, Z., Eiwegger, T. (2014). Genetic Regulation of IgE. In: Mackay, I.R., Rose, N.R., Ledford, D.K., Lockey, R.F. (eds) Encyclopedia of Medical Immunology. Springer, New York, NY. https://doi.org/10.1007/978-1-4614-9194-1_81

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  • DOI: https://doi.org/10.1007/978-1-4614-9194-1_81

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  • Publisher Name: Springer, New York, NY

  • Print ISBN: 978-1-4614-9193-4

  • Online ISBN: 978-1-4614-9194-1

  • eBook Packages: MedicineReference Module Medicine

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