Encyclopedia of Medical Immunology

2014 Edition
| Editors: Ian R. Mackay, Noel R. Rose, Dennis K. Ledford, Richard F. Lockey

Genetic Regulation of IgE

Reference work entry
DOI: https://doi.org/10.1007/978-1-4614-9194-1_81

Definition

Genetic regulation of IgE: influence of genes and variations of genes (polymorphisms) on the propensity of producing immunoglobulin E (IgE) in humans.

Introduction

Atopic diseases such as atopic dermatitis, allergic asthma, allergic rhinitis, and food allergy are based on genetic determinants with a reported heritability of up to 80 % (Cookson and Moffatt 2000; Vercelli 2008; Gould and Sutton 2008). Atopic diseases are typical complex, polygenic traits, which are believed to be influenced by the environment, gene–gene interactions, and multiple genetic variants. A large number of candidate gene studies have been conducted for atopic diseases, results of which were often inconsistent. The candidate genes that could be determined confer either a disease-specific risk or appear to be important for the atopic state rather than for a specific atopic disease. The exclusive assignment of association to either a disease-specific risk or the atopic state very much confines the...

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Copyright information

© Springer-Verlag Berlin Heidelberg 2014

Authors and Affiliations

  1. 1.Division of Pediatric Pulmonology, Allergy and Endocrinology, Department of Pediatrics and Juvenile MedicineMedical University of ViennaViennaAustria
  2. 2.Department of Pediatrics and Adolescent MedicineMedical University of ViennaViennaAustria