Encyclopedia of Medical Immunology

2014 Edition
| Editors: Ian R. Mackay, Noel R. Rose, Dennis K. Ledford, Richard F. Lockey

Specific IgE

Reference work entry
DOI: https://doi.org/10.1007/978-1-4614-9194-1_77

Definition

Immunoglobulins of the IgE heavy chain isotype that are specific for a given antigen/allergen.

Specific IgE

Allergen-specific IgE is the end product of allergen-specific naïve B cells that underwent class switch recombination (CSR) and plasma cell differentiation. At the plasmablast stage, B cells start secreting immunoglobulins, which reach the circulation. Some of these plasmablasts can become long-lived plasma cells, which reside in tissues (primarily the bone marrow) for many years from where they secrete immunoglobulins. This long-term production of immunoglobulins does not require persistent exposure to antigens (Radbruch et al. 2006). The presence of such long-lived plasma cells is a complicating factor for the treatment of allergies since there is no therapy available that targets these bone marrow resident plasma cells. Therefore, once allergen-specific IgE-producing long-lived plasma cells are generated, there is constant production of allergen-specific IgE that...

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References

  1. Aalberse RC, Akkerdaas J, van Ree R. Cross-reactivity of IgE antibodies to allergens. Allergy. 2001;6:478–90.CrossRefGoogle Scholar
  2. Hiller R, Laffer S, Harwanegg C, Huber M, Schmidt WM, Twardosz A, Barletta B, Becker WM, Blaser K, Breiteneder H, Chapman M, Crameri R, Duchene M, Ferreira F, Fiebig H, Hoffmann-Sommergruber K, King TP, Kleber-Janke T, Kurup VP, Lehrer SB, Lidholm J, Muller U, Pini C, Reese G, Scheiner O, Scheynius A, Shen HD, Spitzauer S, Suck R, Swoboda I, Thomas W, Tinghino R, Hage-Hamsten M, Virtanen T, Kraft D, Muller MW, Valenta R. Microarrayed allergen molecules: diagnostic gatekeepers for allergy treatment. FASEB J. 2002;1:414.Google Scholar
  3. Larche M, Akdis CA, Valenta R. Immunological mechanisms of allergen-specific immunotherapy. Nat Rev Immunol. 2006;10:761–71.CrossRefGoogle Scholar
  4. Radbruch A, Muehlinghaus G, Luger EO, Inamine A, Smith KGC, Dorner T, Hiepe F. Competence and competition: the challenge of becoming a long-lived plasma cell. Nat Rev Immunol. 2006;10:741–50.CrossRefGoogle Scholar

Copyright information

© Springer-Verlag Berlin Heidelberg 2014

Authors and Affiliations

  1. 1.Swiss Institute of Allergy and Asthma Research (SIAF)University of ZurichDavos PlatzSwitzerland