Encyclopedia of Medical Immunology

2014 Edition
| Editors: Ian R. Mackay, Noel R. Rose, Dennis K. Ledford, Richard F. Lockey

Safety of Immunotherapy

Reference work entry
DOI: https://doi.org/10.1007/978-1-4614-9194-1_526

Synonyms

Allergen immunotherapy; Allergen-specific desensitization; Allergy immunotherapy; Allergy injections; Allergy shots; Hyposensitization; Immunotherapy

Background

Although the benefits of immunotherapy have been well demonstrated for the treatment of many allergic conditions such as allergic rhinitis, allergic asthma, and stinging insect allergy (Casale and Stokes 2011), the risks of adverse reactions must be considered when immunotherapy is used.

Local Reactions

Localized reactions at the site of immunotherapy injections are fairly common, with frequencies ranging from 26 % to 82 % patients and 0.7 % to 4 % of injections (Cox et al. 2011). These local reactions may involve local erythema, swelling, and itching. In one survey of 249 patients undergoing immunotherapy and who experienced local reactions, 84.7 % reported reactions smaller than the palm of the hand, and 81.9 % classified local reactions as not bothersome at all or only slightly bothersome. Ninety-six percent of...

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References

  1. Calabria CW, Coop CA, Tankersley MS. The LOCAL Study: local reactions do not predict local reactions in allergen immunotherapy. J Allergy Clin Immunol. 2009;124:739–44.PubMedCrossRefGoogle Scholar
  2. Casale TB, Stokes JR. Future forms of immunotherapy. J Allergy Clin Immunol. 2011;127:8–15.PubMedCrossRefGoogle Scholar
  3. Coop CA, Tankersley MS. Patient perceptions regarding local reactions from allergen immunotherapy injections. Ann Allergy Asthma Immunol. 2008;101:96–100.PubMedCrossRefGoogle Scholar
  4. Cox L, Larenas-Linnemann D, Lockey RF, et al. Speaking the same language: the World Allergy Organization Subcutaneous Immunotherapy Systemic Reaction Grading System. J Allergy Clin Immunol. 2010;125:569–74, e7.PubMedCrossRefGoogle Scholar
  5. Cox L, Nelson H, Locke R, et al. Allergen immunotherapy: a practice parameter third update. J Allergy Clin Immunol. 2011;127:S1–55.PubMedCrossRefGoogle Scholar
  6. Nelson HS. Immunotherapy for inhalant allergens. In: Adkinson NF, Bochner BS, Busse WW, Holgate ST, Lemanske RF, Simons FER, editors. Middleton’s allergy: principles and practice. Philadelphia: Elsevier; 2009. p. 1657–77.Google Scholar
  7. Windom HH, Lockey RF. An update on the safety of specific immunotherapy. Curr Opin Allergy Clin Immunol. 2008;8:571–6.PubMedCrossRefGoogle Scholar

Copyright information

© Springer-Verlag Berlin Heidelberg 2014

Authors and Affiliations

  1. 1.Department of Internal Medicine, Division of Allergy and Pulmonary MedicineMayo ClinicJacksonvilleUSA