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Allergic Bronchopulmonary Aspergillosis

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  • First Online:
Encyclopedia of Medical Immunology

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Definition

Allergic bronchopulmonary aspergillosis (ABPA) is a hypersensitivity reaction characterized by recurrent episodes of worsening obstructive lung disease, mucoid impaction, and increased respiratory symptoms in patients who have either asthma or cystic fibrosis (CF), are sensitized to Aspergillus fumigatus, and meet established diagnostic criteria.

Background

Aspergillus fumigatus is a ubiquitous mold that is found both indoor and outdoor. It is present in the air we breathe but also in soil and other outdoor environments that are predisposed to the growth of mold, such as decaying vegetation and mulch, as well as in humid areas like crawl spaces, compost piles, and sewage treatment facilities (Slavin et al. 1988; Paris et al. 1997). In addition to ABPA, which is discussed below, A. fumigatuscan contribute to several pulmonary conditions, such as atopic asthma, hypersensitivity pneumonitis (see separate entry), or invasive disease as is seen in invasive aspergillosis and...

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Author information

Authors and Affiliations

  1. Division of Allergy and Immunology, Department of Internal Medicine, National Jewish Health, 1400 Jackson St, Denver, CO, 80206, USA

    Flavia C. L. Hoyte

Authors
  1. Flavia C. L. Hoyte
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Corresponding author

Correspondence to Flavia C. L. Hoyte .

Editor information

Editors and Affiliations

  1. Department of Biochemistry and Molecular Biology, Monash University, Clayton, Victoria, Australia

    Ian R. Mackay

  2. Center for Autoimmune Disease Research, Department of Molecular Microbiology and Immunology, Department of Pathology, Johns Hopkins University, Baltimore, MD, USA

    Noel R. Rose

  3. Division of Allergy and Immunology, Department of Internal Medicine, University of South Florida Morsani College of Medicine, James A. Haley Veterans' Hospital, Tampa, FL, USA

    Dennis K. Ledford

  4. Division of Allergy and Immunology, Department of Internal Medicine, University of South Florida Morsani College of Medicine, James A. Haley Veterans' Hospital, Tampa, FL, USA

    Richard F. Lockey

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© 2014 Springer-Verlag Berlin Heidelberg

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Hoyte, F.C.L. (2014). Allergic Bronchopulmonary Aspergillosis. In: Mackay, I.R., Rose, N.R., Ledford, D.K., Lockey, R.F. (eds) Encyclopedia of Medical Immunology. Springer, New York, NY. https://doi.org/10.1007/978-1-4614-9194-1_488

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  • DOI: https://doi.org/10.1007/978-1-4614-9194-1_488

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  • Publisher Name: Springer, New York, NY

  • Print ISBN: 978-1-4614-9193-4

  • Online ISBN: 978-1-4614-9194-1

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