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Gluten Intolerance and Skin Diseases

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Encyclopedia of Medical Immunology

Synonyms

Celiac disease; Dermatitis herpetiformis Duhring; Gluten sensitivity; Nontropical sprue

Definition of Gluten Intolerance

In general gluten sensitivity is mainly considered to be linked with celiac disease (CD).

Common denominator for all patients with celiac disease is the presence of a variable combination of the following:

  • Gluten-dependent clinical manifestations

  • Specific autoantibodies

  • HLA DQ2 and/or DQ8 haplotypes

  • Different degrees of enteropathy (Troncone and Jabri 2011)

However, reports of gluten sensitivity without celiac disease date to 1978, when a patient with normal small bowl biopsies and diarrhea was described which improved within days after starting a gluten-free diet (El-Chammas and Danner 2011). Marsh’s “modern” definition of gluten sensitivity describes “a state of heightened immunological responsiveness to ingested gluten in genetically-predisposed individuals,” with such responsiveness being expressed also in organs other than the gastrointestinal tract...

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Author information

Authors and Affiliations

  1. Department of Dermatology and Allergology, University Clinic Marburg, Baldinger Straße, D-35043, Marburg, Germany

    Carlotta Harries

Authors
  1. Carlotta Harries
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Corresponding author

Correspondence to Carlotta Harries .

Editor information

Editors and Affiliations

  1. Department of Biochemistry and Molecular Biology, Monash University, Clayton, Victoria, Australia

    Ian R. Mackay

  2. Center for Autoimmune Disease Research, Department of Molecular Microbiology and Immunology, Department of Pathology, Johns Hopkins University, Baltimore, MD, USA

    Noel R. Rose

  3. Division of Allergy and Immunology, Department of Internal Medicine, University of South Florida Morsani College of Medicine, James A. Haley Veterans' Hospital, Tampa, FL, USA

    Dennis K. Ledford

  4. Division of Allergy and Immunology, Department of Internal Medicine, University of South Florida Morsani College of Medicine, James A. Haley Veterans' Hospital, Tampa, FL, USA

    Richard F. Lockey

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© 2014 Springer-Verlag Berlin Heidelberg

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Harries, C. (2014). Gluten Intolerance and Skin Diseases. In: Mackay, I.R., Rose, N.R., Ledford, D.K., Lockey, R.F. (eds) Encyclopedia of Medical Immunology. Springer, New York, NY. https://doi.org/10.1007/978-1-4614-9194-1_466

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  • DOI: https://doi.org/10.1007/978-1-4614-9194-1_466

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  • Publisher Name: Springer, New York, NY

  • Print ISBN: 978-1-4614-9193-4

  • Online ISBN: 978-1-4614-9194-1

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