Gluten Intolerance and Skin Diseases
Celiac disease; Dermatitis herpetiformis Duhring; Gluten sensitivity; Nontropical sprue
Definition of Gluten Intolerance
In general gluten sensitivity is mainly considered to be linked with celiac disease (CD).
Gluten-dependent clinical manifestations
HLA DQ2 and/or DQ8 haplotypes
Different degrees of enteropathy (Troncone and Jabri 2011)
However, reports of gluten sensitivity without celiac disease date to 1978, when a patient with normal small bowl biopsies and diarrhea was described which improved within days after starting a gluten-free diet (El-Chammas and Danner 2011). Marsh’s “modern” definition of gluten sensitivity describes “a state of heightened immunological responsiveness to ingested gluten in genetically-predisposed individuals,” with such responsiveness being expressed also in organs other than the gastrointestinal tract...