Encyclopedia of Malaria

Living Edition
| Editors: Peter G. Kremsner, Sanjeev Krishna

Coenzyme A Biosynthesis

Living reference work entry
DOI: https://doi.org/10.1007/978-1-4614-8757-9_42-1

Synonyms

Definition

A biosynthetic process for the generation of coenzyme A. The pathway generally involves five enzyme-mediated steps and pantothenate (vitamin B5), cysteine, and ATP (and sometimes CTP) as substrates.

Introduction

During its intraerythrocytic cycle, the malaria parasite requires an extracellular supply of various nutrients (Kirk and Saliba 2007; Saliba and Kirk 2001b), including the water-soluble vitamin pantothenate (also known as vitamin B5). Pantothenate is a precursor to coenzyme A (CoA), an important coenzyme for many biochemical reactions that has been estimated to be used by as many as 9 % of all known enzymes (Strauss 2010). Early in vivo studies with...

Keywords

Tuberculosis Folate Malaria Cytosol Butyl 
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Copyright information

© Springer Science+Business Media New York 2015

Authors and Affiliations

  1. 1.Medical SchoolThe Australian National UniversityCanberraAustralia
  2. 2.Research School of BiologyThe Australian National UniversityCanberraAustralia
  3. 3.Department of ChemistryUniversity of CambridgeCambridgeUK