Coenzyme A Biosynthesis
CoA biosynthesis: pantothenate metabolism; Coenzyme A: CoA, CoASH, [[(2R,3S,4R,5R)-5-(6-aminopurin-9-yl)-4-hydroxy-3-phosphonooxyoxolan-2-yl]methoxy-hydroxyphosphoryl][(3R)-3-hydroxy-2,2-dimethyl-4-oxo-4-[[3-oxo-3-(2-sulfanylethylamino)propyl]amino]butyl]hydrogen phosphate (IUPAC name); Pantothenate: vitamin B5
A biosynthetic process for the generation of coenzyme A. The pathway generally involves five enzyme-mediated steps and pantothenate (vitamin B5), cysteine, and ATP (and sometimes CTP) as substrates.
During its intraerythrocytic cycle, the malaria parasite requires an extracellular supply of various nutrients (Kirk and Saliba 2007; Saliba and Kirk 2001b), including the water-soluble vitamin pantothenate (also known as vitamin B5). Pantothenate is a precursor to coenzyme A (CoA), an important coenzyme for many biochemical reactions that has been estimated to be used by as many as 9 % of all known enzymes (Strauss 2010). Early in vivo studies with...
KeywordsTuberculosis Folate Malaria Cytosol Butyl
- Strauss E. Coenzyme A biosynthesis and enzymology. In: Mander L, Liu H-W, editors. Comprehensive natural products II - Chemistry and biology, vol. 7. Oxford: Elsevier; 2010. pp. 351–410.Google Scholar