Permeabilization of Host Cell Membrane
By replicating within red blood cells, malaria parasites are largely hidden from immune recognition, but parasites enter an unusual closed environment where some nutrients are limited and where accumulation of hazardous metabolic end products can rapidly become deleterious. Therefore, to survive within erythrocytes, parasites circumvent the relative low permeability of the host plasma membrane by altering the permeability of the host plasma membrane either by upregulating existing carriers or by creating new permeation pathways (NPPs). Recent electrophysiological studies of Plasmodium-infected erythrocytes have demonstrated that these changes reflect transmembrane transports through ion channels or pores in the infected erythrocyte.
The intraerythrocytic stage of malaria parasite’s life cycle allows Plasmodiumgenus to escape host immune system threatening and recognition. However, by...
KeywordsPermeability Lactate Methionine Malaria Cytosol
The labex GR-Ex, reference ANR-11-LABX-0051 is funded by the program “Investissements d’avenir” of the French National Research Agency, reference ANR-11-IDEX-0005-02.
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