Definition
Red blood cells evolved to provide the most efficient machinery for transporting the vital respiratory gases oxygen and CO2between lungs and tissues, with minimal energy waste. In mammals, ultimate energy economy was attained by the red cells shedding the nucleus and all intracellular organelles and by reducing to a minimum all the energy-requiring membrane traffic of the ions essential for the maintenance and control of cell volume throughout the long circulatory life span of the cells. Infection of a red blood cell by a malaria parasite dramatically disrupts this low-energy balance by massively increasing the metabolic activity and membrane traffic of the infected cell. How the parasite prevents the host cell from swelling and bursting prematurely, before the...
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References
Abkarian M, Massiera G, Berry L, Roques M, Braun-Breton C. A novel mechanism for egress of malarial parasites from red blood cells. Blood. 2011;117:4118–24.
Bouyer G, Cueff A, Egee S, Kmiecik J, Maksimova Y, Glogowska E, Gallagher PG, Thomas SL. Erythrocyte peripheral type benzodiazepine receptor/voltage-dependent anion channels are upregulated by Plasmodium falciparum. Blood. 2011;118:2305–12.
Clark MR. Senescence of red blood cells: progress and problems. Physiol Rev. 1988;68:503–54.
Cowman AF, Crabb BS. Invasion of red blood cells by malaria parasites. Cell. 2006;124:755–66.
Desai SA, Rosenberg RL. Pore size of the malaria parasite’s nutrient channel. Proc Natl Acad Sci U S A. 1997;94:2045–9.
Dvorak JA, Miller LH, Whitehouse WC, Shiroishi T. Invasion of erythrocytes by malaria merozoites. Science. 1975;187:748–50.
Gilson PR, Crabb BS. Morphology and kinetics of the three distinct phases of red blood cell invasion by Plasmodium falciparum merozoites. Int J Parasitol. 2009;39:91–6.
Ginsburg H, Krugliak M, Eidelman O, Cabantchik ZI. New permeability pathways induced in membranes of Plasmodium falciparum infected erythrocytes. Mol Biochem Parasitol. 1983;8:177–90.
Glushakova S, Yin D, Li T, Zimmerberg J. Membrane transformation during malaria parasite release from human red blood cells. Curr Biol. 2005;15:1645–50.
Kirk K. Membrane transport in the malaria-infected erythrocyte. Physiol Rev. 2001;81:495–537.
Krugliak M, Zhang J, Ginsburg H. Intraerythrocytic Plasmodium falciparum utilizes only a fraction of the amino acids derived from the digestion of host cell cytosol for the biosynthesis of its proteins. Mol Biochem Parasitol. 2002;119:249–56.
Lee P, Ye Z, Van Dyke K, Kirk RG. X-ray microanalysis of Plasmodium falciparum and infected red blood cells: effects of qinghaosu and chloroquine on potassium, sodium, and phosphorus composition. Am J Trop Med Hyg. 1988;39:157–65.
Lew VL. Malaria: endless fascination with merozoite release. Curr Biol. 2005;15:R760–1.
Lew VL. Malaria: surprising mechanism of merozoite egress revealed. Curr Biol. 2011;21:R314–6.
Lew VL, Tiffert T. Is invasion efficiency in malaria controlled by pre-invasion events? Trends Parasitol. 2007;23:481–4.
Lew VL, Tiffert T, Ginsburg H. Excess hemoglobin digestion and the osmotic stability of Plasmodium falciparum-infected red blood cells. Blood. 2003;101:4189–94.
Lew VL, Macdonald L, Ginsburg H, Krugliak M, Tiffert T. Excess haemoglobin digestion by malaria parasites: a strategy to prevent premature host cell lysis. Blood Cells Mol Dis. 2004;32:353–9.
Lew VL, Daw N, Etzion Z, Tiffert T, Muoma A, Vanagas L, Bookchin RM. Effects of age-dependent membrane transport changes on the homeostasis of senescent human red blood cells. Blood. 2007;110:1334–42.
Lutz HU. Naturally occurring autoantibodies in mediating clearance of senescent red blood cells. Adv Exp Med Biol. 2012;750:76–90.
Mauritz JM, Esposito A, Ginsburg H, Kaminski CF, Tiffert T, Lew VL. The homeostasis of Plasmodium falciparum-infected red blood cells. PLoS Comput Biol. 2009;5:e1000339.
Mauritz JM, Seear R, Esposito A, Kaminski CF, Skepper JN, Warley A, Lew VL, Tiffert T. X-ray microanalysis investigation of the changes in Na, K, and hemoglobin concentration in Plasmodium falciparum-infected red blood cells. Biophys J. 2011;100:1438–45.
Nguitragool W, Bokhari AA, Pillai AD, Rayavara K, Sharma P, Turpin B, Aravind L, Desai SA. Malaria parasite clag3 genes determine channel-mediated nutrient uptake by infected red blood cells. Cell. 2011;145:665–77.
Park Y, Diez-Silva M, Popescu G, Lykotrafitis G, Choi W, Feld MS, Suresh S. Refractive index maps and membrane dynamics of human red blood cells parasitized by Plasmodium falciparum. Proc Natl Acad Sci U S A. 2008;105:13730–5.
Pasvol G, Weatherall DJ, Wilson RJ. The increased susceptibility of young red cells to invasion by the malarial parasite Plasmodium falciparum. Br J Haematol. 1980;45:285–95.
Saliba KJ, Martin RE, Broer A, Henry RI, McCarthy CS, Downie MJ, Allen RJ, Mullin KA, McFadden GI, Broer S, Kirk K. Sodium-dependent uptake of inorganic phosphate by the intracellular malaria parasite. Nature. 2006;443:582–5.
Staines HM, Ellory JC, Kirk K. Perturbation of the pump-leak balance for Na+ and K+ in malaria- infected erythrocytes. Am J Physiol Cell Physiol. 2001;280:C1576–87.
Tiffert T, Lew VL, Ginsburg H, Krugliak M, Croisille L, Mohandas N. The hydration state of human red blood cells and their susceptibility to invasion by Plasmodium falciparum. Blood. 2005;105:4853–60.
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Lew, V.L., Tiffert, T. (2013). Volume Control. In: Hommel, M., Kremsner, P. (eds) Encyclopedia of Malaria. Springer, New York, NY. https://doi.org/10.1007/978-1-4614-8757-9_27-1
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DOI: https://doi.org/10.1007/978-1-4614-8757-9_27-1
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