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Glycolysis

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Encyclopedia of Malaria

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Synonyms

Embden-Meyerhof-Parnas pathway

Definition

Glycolysis, occurring in cytoplasm of almost all organisms, can be defined as a metabolic pathway consisting of ten enzyme-catalyzed reactions that degrade glucose to pyruvate with the formation of high-energy ATP and NADH. Although oxygen is not required, the terms – aerobic and anaerobic glycolysis – are frequently used. The latter pathway, of relevance here, involves regeneration of NAD+ with lactate formation.

Introduction

Malaria in humans is caused by six known species of Plasmodium. These are P. falciparum, P. vivax, P. ovale curtisi, P. ovale wallikeri, P. malariae, and P. knowlesi. The parasite has a complex life cycle with anopheles mosquito as the definitive host and has adapted to the different environments in the insect and vertebrate hosts. In mosquitoes, the growth is largely extracellular and aerobic. In vertebrates the environments are comparatively glucose-rich; growth is largely intracellular and exhibits anaerobic...

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Authors and Affiliations

  1. Department of Biological Sciences, Tata Institute of Fundamental Research, Homi Bhabha Road, Mumbai, 400 005, India

    Shobhona Sharma & Gotam K. Jarori

  2. Department of Chemical Sciences, Tata Institute of Fundamental Research, Homi Bhabha Road, Mumbai, 400 005, India

    Haripalsingh M. Sonawat

Authors
  1. Shobhona Sharma
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  2. Gotam K. Jarori
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  3. Haripalsingh M. Sonawat
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Correspondence to Haripalsingh M. Sonawat .

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Editors and Affiliations

  1. Heswall, United Kingdom

    Marcel Hommel

  2. Institut für Tropenmedizin, Universität Tübingen, Tübingen, Germany

    Peter G. Kremsner

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Sharma, S., Jarori, G.K., Sonawat, H.M. (2013). Glycolysis. In: Hommel, M., Kremsner, P. (eds) Encyclopedia of Malaria. Springer, New York, NY. https://doi.org/10.1007/978-1-4614-8757-9_21-1

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