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History of Discoveries, Malaria

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Encyclopedia of Malaria

Synonyms

Chronology, Research history

Definition

A description of some of the major research studies and discoveries in the mechanisms of malaria disease, in their historical context.

There are obvious reasons for caution when trying to answer this title’s question. First, advances are increasingly made by a team or by more than one team at about the same time – ascribing credit is uncertain and hazardous. Second, advances commonly consist of a chain of discoveries, each dependent on the last, and all being necessary to the progress in question – it can be difficult to decide which link in the chain is crucial. Third, in many areas – especially in severe and fatal disease – the pathophysiology of malaria is still not fully understood, and therefore it is not possible to judge which advances in the history of malaria research will eventually prove to have been “significant.”

No two authors would come up with the same list of important advances in the pathophysiology of malaria; the...

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References

  • Abdalla S, Weatherall DJ, Wickramasinghe SN, Hughes M. The anaemia of P. falciparum malaria. Br J Haematol. 1980;46(2):171–83.

    Article  CAS  PubMed  Google Scholar 

  • Allison AC. Protection afforded by sickle-cell trait against subtertian malaria infection. Br Med J. 1954;1:290–4.

    Article  CAS  PubMed Central  PubMed  Google Scholar 

  • Atkins E, Wood Jr WB. Studies on the pathogenesis of fever II Identification of an endogenous pyrogen in the blood stream following the injection of typhoid vaccine. J Exp Med. 1955;102(5):499–516.

    Article  CAS  PubMed Central  PubMed  Google Scholar 

  • Beare NA, Harding SP, Taylor TE, Lewallen S, Molyneux ME. Perfusion abnormalities in children with cerebral malaria and malarial retinopathy. J Infect Dis. 2009;199:263–71.

    Article  PubMed Central  PubMed  Google Scholar 

  • Berkley JA, Lowe BS, Mwangi I, Williams T, Bauni E, Mwarumba S, Ngetsa C, Slack MP, Njenga S, Hart CA, Maitland K, English M, Marsh K, Scott JA. Bacteremia among children admitted to a rural hospital in Kenya. N Engl J Med. 2005;352:39–47.

    Article  CAS  PubMed  Google Scholar 

  • Blatteis CM. The onset of fever: new insights into its mechanism. Prog Brain Res. 2007;162:3–14.

    Article  CAS  PubMed  Google Scholar 

  • Boutlis CS, Riley EM, Anstey NM, de Souza JB. Glycosylphosphatidylinositols in malaria pathogenesis and immunity: potential for therapeutic inhibition and vaccination. Curr Top Microbiol Immunol. 2005;297:145–85.

    CAS  PubMed  Google Scholar 

  • Brown H, Hien TT, Day N, Mai NT, Chuong LV, Chau TT, Loc PP, Phu NH, Bethell D, Farrar J, Gatter K, White N, Turner G. Evidence of blood–brain barrier dysfunction in human cerebral malaria. Neuropathol Appl Neurobiol. 1999;25(4):331–40.

    Article  CAS  PubMed  Google Scholar 

  • Buffet PA, Milon G, Brousse V, et al. Ex vivo perfusion of human spleens maintains clearing and processing functions. Blood. 2006;107(9):3745–52.

    Article  CAS  PubMed  Google Scholar 

  • Buffet PA, Safeukui I, Deplaine G, Brousse V, Prendki V, Thellier M, Turner GD, Mercereau-Puijalon O. The pathogenesis of Plasmodium falciparum malaria in humans: insights from splenic physiology. Blood. 2011;117(2):381–92.

    Article  CAS  PubMed Central  PubMed  Google Scholar 

  • Calis JC, Phiri KS, Faragher EB, Brabin BJ, Bates I, Cuevas LE, de Haan RJ, Phiri AI, Malange P, Khoka M, Hulshof PJ, van Lieshout L, Beld MG, Teo YY, Rockett KA, Richardson A, Kwiatkowski DP, Molyneux ME, van Hensbroek MB. Severe anemia in Malawian children. N Engl J Med. 2008;358(9):888–99.

    Article  CAS  PubMed  Google Scholar 

  • Chang KH, Stevenson MM. Malarial anaemia: mechanisms and implications of insufficient erythropoiesis during blood-stage malaria. Int J Parasitol. 2004;34:1501–16.

    Article  CAS  PubMed  Google Scholar 

  • Clark IA, Budd AC, Alleva LM, Cowden WB. Human malarial disease: a consequence of inflammatory cytokine release. Malar J. 2006;5:85.

    Article  PubMed Central  PubMed  Google Scholar 

  • Cox, Francis EG. “History of the discovery of the malaria parasites and their vectors”. Parasites & Vectors 2010;3(1):5.

    Article  Google Scholar 

  • Craig A, Scherf A. Molecules on the surface of the Plasmodium falciparum infected erythrocyte and their role in malaria pathogenesis and immune evasion. Mol Biochem Parasitol. 2001;115:129–43.

    Article  CAS  PubMed  Google Scholar 

  • Cranston HA, Boylan CW, Carroll GL, Sutera SP, Williamson JR, Gluzman IY, Krogstad DJ. Plasmodium falciparum maturation abolishes physiologic red cell deformability. Science. 1984;223(4634):400–3.

    Article  CAS  PubMed  Google Scholar 

  • Cunnington AJ, de Souza JB, Walther M, Riley EM. Malaria impairs resistance to Salmonella through heme- and heme oxygenase-dependent dysfunctional granulocyte mobilization. Nat Med. 2011;18:120–7.

    Article  PubMed Central  PubMed  Google Scholar 

  • Cunnington AJ, Njie M, Correa S, Takem EN, Riley EM, Walther M. Prolonged neutrophil dysfunction after Plasmodium falciparum malaria is related to hemolysis and heme oxygenase-1 induction. J Immunol. 2012;189(11):5336–46.

    Article  CAS  PubMed Central  PubMed  Google Scholar 

  • Dinarello CA. IL-1: discoveries, controversies and future directions. Eur J Immunol. 2010;40(3):599–606.

    Article  CAS  PubMed  Google Scholar 

  • Dondorp AM, Pongponratn E, White NJ. Reduced microcirculatory flow in severe falciparum malaria: pathophysiology and electron-microscopic pathology. Acta Trop. 2004;89(3):309–17.

    Article  PubMed  Google Scholar 

  • Dorovini-Zis K, Schmidt K, Huynh H, Wenjiang F, Whitten RO, Milner D, Kamiza S, Molyneux ME, Taylor TE. The neuropathology of fatal cerebral malaria in Malawian children. Am J Pathol. 2011;178(5):2146–58.

    Article  PubMed Central  PubMed  Google Scholar 

  • Golenda CF, Li J, Rosenberg R. Continuous in vitro propagation of the malaria parasite Plasmodium vivax. Proc Nat Acad Sci. 1997;94(13):6786–91.

    Article  CAS  PubMed Central  PubMed  Google Scholar 

  • Golgi C. Sull’infezione malarica. Arch Sci Med. 1886;10:109–35.

    Google Scholar 

  • Grassi B, Feletti R. Sui parassiti della malaria. Rif. Med. 1890;6:62–64.

    Google Scholar 

  • Haldane JBS. Disease and evolution. Ric Sci Suppl A. 1949;19:68–76.

    Google Scholar 

  • Hollestelle MJ, Donkor C, Mantey EA, Chakravorty SJ, Craig A, Akoto AO, O’Donnell J, van Mourik JA, Bunn J. von Willebrand factor propeptide in malaria: evidence of acute endothelial cell activation. Br J Haematol. 2006;133(5):562–9.

    Article  CAS  PubMed  Google Scholar 

  • Klebs E, Tommasi-Crudeli C. Studi sulla natura della malaria. Atti R Accad Lincei. 1879;4:172–236.

    Google Scholar 

  • Krishna S, Waller DW, ter Kuile F, Kwiatkowski D, Crawley J, Craddock CF, Nosten F, Chapman D, Brewster D, Holloway PA, et al. Lactic acidosis and hypoglycaemia in children with severe malaria: pathophysiological and prognostic significance. Trans R Soc Trop Med Hyg. 1994;88(1):67–73.

    Article  CAS  PubMed  Google Scholar 

  • Kwiatkowski D, Molyneux ME, Stephens S, Curtis N, Klein N, Pointaire P, Smit M, Allan R, Brewster DR, Grau GE, et al. Anti-TNF therapy inhibits fever in cerebral malaria. Q J Med. 1993;86(2):91–8.

    CAS  PubMed  Google Scholar 

  • Lamikanra AA, Brown D, Potocnik A, Casals-Pascual C, Langhorne J, Roberts DJ. Malarial anemia: of mice and men. Blood. 2007;110(1):18–28.

    Article  CAS  PubMed  Google Scholar 

  • Laveran CLA. Note sur un nouveau parasite trouve dans le sang de plusiers malades atteints de fievre palustres. Bull Acad Med. 1880;9:1235.

    Google Scholar 

  • Looareesuwan S, Ho M, Wattanagoon Y, et al. Dynamic alteration in splenic function during acute falciparum malaria. N Engl J Med. 1987;317(11):675–9.

    Article  CAS  PubMed  Google Scholar 

  • Luse SA, Miller LH. Plasmodium falciparum malaria: ultrastructure of parasitized erythrocytes in cardiac vessels. Am J Trop Med Hyg. 1971;20:655.

    CAS  PubMed  Google Scholar 

  • Maegraith BG. Is there a malaria toxin? J Gen Microbiol. 1969;59: xi

    Google Scholar 

  • Marsh K, Forster D, Waruiru C, et al. Indicators of life-threatening malaria in African children. N Engl J Med. 1995;332:1399–404.

    Article  CAS  PubMed  Google Scholar 

  • Meckel H. “Ueber schwarzes Pigment in der Milz und dem Blute einer Geisteskranken”. Zeitschrift für Psychiatrie IV. 1847; 198–226.

    Google Scholar 

  • Medana IM, Turner GD. Human cerebral malaria and the blood–brain barrier. Int J Parasitol. 2006;36(5):555–68.

    Article  CAS  PubMed  Google Scholar 

  • Miller LH, Mason SJ, Clyde DF, McGinnis MH. The resistance factor to Plasmodium vivax in blacks: the Duffy blood group genotype Fy-Fy-. N Engl J Med. 1976;295:302–4.

    Article  CAS  PubMed  Google Scholar 

  • Molyneux ME, Taylor TE, Wirima JJ, Borgstein A. Clinical features and prognostic indicators in paediatric cerebral malaria: a study of 131 comatose Malawian children. Q J Med. 1989;71(265):441–59.

    CAS  PubMed  Google Scholar 

  • Moon RW, Hall J, Rangkuti F, Ho YS, Almond N, Mitchell GH, Pain A, Holder AA, Blackman MJ. Adaptation of the genetically tractable malaria pathogen Plasmodium knowlesi to continuous culture in human erythrocytes. Proc Natl Acad Sci U S A. 2013;110(2):531–6.

    Article  CAS  PubMed Central  PubMed  Google Scholar 

  • Moxon CA, Heyderman RS, Wassmer SC. Dysregulation of coagulation in cerebral malaria. Mol Biochem Parasitol. 2009;166(2):99–108.

    Article  CAS  PubMed Central  PubMed  Google Scholar 

  • Planche T, Onanga M, Schwenk A, Dzeing A, Borrmann S, Faucher JF, Wright A, Bluck L, Ward L, Kombila M, Kremsner PG, Krishna S. Assessment of volume depletion in children with malaria. PLoS Med. 2004;1(1):e18. Epub 2004 Oct 19.

    Article  PubMed Central  PubMed  Google Scholar 

  • Pongponratn E, Turner GD, Day NP, Phu NH, Simpson JA, Stepniewska K, Mai NT, Viriyavejakul P, Looareesuwan S, Hien TT, Ferguson DJ, White NJ. An ultrastructural study of the brain in fatal Plasmodium falciparum malaria. Am J Trop Med Hyg. 2003;69(4):345–59.

    PubMed  Google Scholar 

  • Rogerson SJ. Sequestration: causes and consequences. Redox Rep. 2003;8(5):295–9.

    Article  CAS  PubMed  Google Scholar 

  • Rosenberg EB, Strickland GT, Yang SL, Whalen GE. Antibodies to red cells and autoimmune anemia in patients with malaria. Am J Trop Med Hyg. 1973;22(2):146–52.

    CAS  PubMed  Google Scholar 

  • Rowe JA, Claessens A, Corrigan RA, Arman M. Adhesion of Plasmodium falciparum-infected erythrocytes to human cells: molecular mechanisms and therapeutic implications. Expert Rev Mol Med. 2009;11:e16.

    Article  PubMed Central  PubMed  Google Scholar 

  • Safeukui I, Correas JM, Brousse V, et al. Retention of Plasmodium falciparum ring-infected erythrocytes in the slow, open microcirculation of the human spleen. Blood. 2008;112(6):2520–8.

    Article  CAS  PubMed  Google Scholar 

  • Schofield L, Hackett F. Signal transduction in host cells by a glycosylphosphatidylinositol toxin of malaria parasites. J Exp Med. 1993;177:145–53.

    Article  CAS  PubMed  Google Scholar 

  • Sinton JA, Kehar ND. Changes in the amount of blood sugar in malaria. Rec Mal Surv India. 1931;2:287–304.

    Google Scholar 

  • Snounou G, Perignon J-L. Malariotherapy: insanity at the service of malariology. Adv Parasitol. 2013;81(6):223–55.

    Article  PubMed  Google Scholar 

  • Stephens JWW. A new malaria parasite of man. Ann Trop Med Parasitol. 1922;16:383–8.

    Google Scholar 

  • Taylor TE, Molyneux ME, Wirima JJ, Fletcher KA, Morris K. Blood glucose levels in Malawian children before and during the administration of intravenous quinine for severe falciparum malaria. N Engl J Med. 1988;319(16):1040–7.

    Article  CAS  PubMed  Google Scholar 

  • Taylor TE, Borgstein A, Molyneux ME. Acid–base status in paediatric Plasmodium falciparum malaria. Q J Med. 1993;86(2):99–109.

    CAS  PubMed  Google Scholar 

  • Trager W, Jensen JB. Human malaria parasites in continuous culture. Science. 1976;193:673–5.

    Article  CAS  PubMed  Google Scholar 

  • Trang TT, Phu NH, Vinh H, Hien TT, Cuong BM, Chau TT, Mai NT, Waller DJ, White NJ. Acute renal failure in patients with severe falciparum malaria. Clin Infect Dis. 1992;15(5):874–80.

    Article  CAS  PubMed  Google Scholar 

  • Udeinya IJ, Schmidt JA, Aikawa M, Miller LH, Green I. Falciparum malaria-infected erythrocytes specifically bind to cultured human endothelial cells. Science. 1981;213:555–7.

    Article  CAS  PubMed  Google Scholar 

  • Udomsangpetch R, Kaneko O, Chotivanich K, Sattabongkot J. Cultivation of Plasmodium vivax. Trends Parasitol. 2008;24(2):85–8.

    Article  PubMed  Google Scholar 

  • van Hensbroek MB, Palmer A, Onyiorah E, Schneider G, Jaffar S, Dolan G, Memming H, Frenkel J, Enwere G, Bennett S, Kwiatkowski D, Greenwood B. The effect of a monoclonal antibody to tumor necrosis factor on survival from childhood cerebral malaria. J Infect Dis. 1996;174(5):1091–7.

    Article  PubMed  Google Scholar 

  • van Hensbroek MB, Calis JCJ, Phiri KS, Vet R, Munthali F, Kraaijenhagen R, van den Berg H, Faragher B, Bates I, Molyneux ME. Pathophysiological mechanisms of severe anemia in Malawian children. PLoS One. 2010;5(9):e12589.

    Article  Google Scholar 

  • White NJ, Turner GD, Day NP, Dondorp AM. Lethal malaria: Marchiafava and Bignami were right. J Infect Dis. 2013;208(2):192–8.

    Article  CAS  PubMed Central  PubMed  Google Scholar 

  • Woodruff AW, Ansdell VE, Pettitt LE. Cause of anaemia in malaria. Lancet. 1979;1(8125):1055–7.

    Article  CAS  PubMed  Google Scholar 

  • Yeo TW, Lampah DA, Kenangalem E, Tjitra E, Price RN, Anstey NM. Impaired skeletal muscle microvascular function and increased skeletal muscle oxygen consumption in severe falciparum malaria. J Infect Dis. 2013;207(3):528–36.

    Article  PubMed Central  PubMed  Google Scholar 

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Correspondence to Malcolm E. Molyneux .

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Molyneux, M.E. (2013). History of Discoveries, Malaria. In: Hommel, M., Kremsner, P. (eds) Encyclopedia of Malaria. Springer, New York, NY. https://doi.org/10.1007/978-1-4614-8757-9_115-1

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  • DOI: https://doi.org/10.1007/978-1-4614-8757-9_115-1

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