Synonyms
Definition
Emerging diagnostic platforms for malaria consist of novel methods to detect Plasmodium antigens, nucleic acids, unique metabolites, or unique cell-based changes within infected erythrocytes in blood or in non-blood sources. Although assessing the severity of malaria and confirming disease syndromes are also a clinical priority, methods for this are not discussed here.
Background
Emerging technologies (Mehta and Cook 2010; UNITAID 2011) for the diagnosis of malaria are inevitably assessed against existing platforms, and these are themselves undergoing refinements. Their evolution, and the basis for justifying the development of new technologies, is motivated by the goals of improving diagnostic accuracy, making tests simpler to use – including noninvasive approaches – making less expensive tests, and providing added value for results such as co-detection of drug resistance markers. The incidence of malaria is...
This is a preview of subscription content, log in via an institution to check access.
References
Day NP, Pham TD, Phan TL, et al. Clearance kinetics of parasites and pigment-containing leukocytes in severe malaria. Blood. 1996;88(12):4694–700.
Desakorn V, Dondorp AM, Silmut K, et al. Stage-dependent production and release of histidine-rich protein 2 by Plasmodium falciparum. Trans R Soc Trop Med Hyg. 2005;99:517–24.
FIND Diagnostics. 2015. http://www.finddiagnostics.org/programs/malaria-afs/
Hanscheid T, Egan TJ, Grobusch MP. Haemozoin: from melatonin pigment to drug target, diagnostic tool, and immune modulator. Lancet Infect Dis. 2007;7(10):675–85.
Lukianova-Hleb EY, Campbell KM, Constantinou PE, et al. Hemozoin-generated vapor nanobubbles for transdermal reagent- and needle-free detection of malaria. Proc Natl Acad Sci USA. 2014;111:900–5.
Mehta P, Cook D. The diagnostics innovation map: medial diagnostics for the unmet needs of the developing world. 2010. BIO Ventures for Global Health. http://www.bvgh.org/LinkClick.aspx?fileticket=−a1C6u2LE4w%3d&tabid=91
Sullivan D. Hemozoin: a biocrystal synthesized during the degradation of hemoglobin. In: Matsumura S, Steinbüchel A, editors. Miscellaneous biopolymers, biodegradation of synthetic polymers. 1st ed. Weinheim: Wiley-VCH; 2002. p. 129–63.
UNITAID. Malaria diagnostic technology landscape. 2011. Daily J.
Author information
Authors and Affiliations
Corresponding author
Editor information
Editors and Affiliations
Rights and permissions
Copyright information
© 2014 Springer Science+Business Media New York
About this entry
Cite this entry
Krishna, S., Sullivan, D.J. (2014). Emerging Diagnostic Platforms for Malaria. In: Hommel, M., Kremsner, P. (eds) Encyclopedia of Malaria. Springer, New York, NY. https://doi.org/10.1007/978-1-4614-8757-9_112-1
Download citation
DOI: https://doi.org/10.1007/978-1-4614-8757-9_112-1
Received:
Accepted:
Published:
Publisher Name: Springer, New York, NY
Online ISBN: 978-1-4614-8757-9
eBook Packages: Springer Reference MedicineReference Module Medicine