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Malaria Diagnostic Platform, Hemozoin Detection

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Encyclopedia of Malaria

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Synonyms

B-hematin; Dark-field microscopy; Fe(III)protoporphyrin IX; Ferriprotoporphyrin IX; Hemozoin; Malaria pigment

Definition

Hemozoin, a chemically inert, insoluble crystalline dimer of ferriprotoporphyrin IX, is intrinsic to malaria parasite metabolism and has unique optical and magnetic properties which make it an attractive biomarker for malaria diagnostics. Hemozoin has been detected in blood samples using various spectroscopic, magneto-optic, optical scattering, and nonlinear optical methods.

Background

Malaria is a mosquito-borne parasite that infects nearly 220 million people worldwide, causing ~ 1 million deaths/year, many of whom are African children. Accurate and cost-effective diagnostics are an important component of efforts to reduce the malaria burden. Today, malaria is typically diagnosed by microscopic identification of the parasite or by lateral flow immunological assays similar to pregnancy tests. However, even with the most optimistic deployment strategies, it...

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Authors and Affiliations

  1. Intellectual Ventures Laboratory, 1555 132nd Ave. NE, 98005, Bellevue, WA, USA

    Michael C. Hegg

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  1. Michael C. Hegg
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Correspondence to Michael C. Hegg .

Editor information

Editors and Affiliations

  1. Institut für Tropenmedizin, Universität Tübingen, Tübingen, Germany

    Peter G. Kremsner

  2. Medical School, St. George's, University of London Medical School, New Malden, United Kingdom

    Sanjeev Krishna

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Hegg, M.C. (2014). Malaria Diagnostic Platform, Hemozoin Detection. In: Kremsner, P., Krishna, S. (eds) Encyclopedia of Malaria. Springer, New York, NY. https://doi.org/10.1007/978-1-4614-8757-9_110-1

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  • DOI: https://doi.org/10.1007/978-1-4614-8757-9_110-1

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  • Online ISBN: 978-1-4614-8757-9

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