Glucose-6-Phosphate Dehydrogenase Deficiency and Primaquine Hemolytic Toxicity
Primaquine as an oxidative drug can produce lethal side effect in G6PD-deficient individual.
Clinical and Public Health Importance
Glucose-6-phosphate dehydrogenase deficiency (G6PDd) is a vitally important problem in malaria treatment, control, and elimination. It is the most common genetic disorder in humans, affecting about 400 million people (Beutler 1994). In populations living where malaria is endemic, the prevalence of the defect averages about 8 % (Howes 2012), very probably because G6PDd provides a survival advantage against the infection (Clark et al. 2009) as shown in Fig. 1. G6PDd exhibits enormous diversity, both in terms of residual enzyme activity phenotype (spanning from <1 % to 150 %) and underlying genotypes (many dozens of clinically significant mutants are known) (Minucci 2012). Mutations occur all along the length of this very large...
KeywordsResidual Enzyme Activity G6PD Activity Cytochemical Staining Hemizygous Male Hexose Monophosphate Shunt
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