Parenteral Nutrition in Advanced Cancer

  • Edward M. CopelandIII
Living reference work entry


Nutritional repletion by gastrointestinal tract or central vein has now been established to replenish or preserve lean body mass which prevents multiple complications in treatments with chemotherapy, surgery, and radiation therapy. These treatments may result in catabolism with the inability to repair wounds, to mount an appropriate chemotactic response to infection, or to avoid the effects of immunosuppression. Total parenteral nutrition can reverse catabolism in the appropriately selected patients. Patients with advanced cancer already have altered metabolism that can result in all the complications of malnutrition. An attempt to treat these patients with any form of anticancer therapy that results in further catabolism may result in the need to place these patients in an intensive care unit. The purpose of this chapter is to present the data in a historical fashion that proves the salutary effect of nutritional repletion. The evidence is provided that patients with advanced cancer can withstand treatment appropriate for their malignancy, have the chance for a positive tumor response, and have a significantly reduced chance of untoward complications of malnutrition secondary to the selected anticancer therapy.


Central Venous Catheter Skin Test Infectious Complication Lean Body Mass Malnourished Patient 
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List of Abbreviations




Bone marrow transplant


Eicosapentaenoic acid

g/100 ml

Grams per 100 ml


Intensive care unit


Intravenous hyperalimentation


MD Anderson Hospital and Tumor Institute


Total parenteral nutrition


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Copyright information

© Springer Science+Business Media New York 2014

Authors and Affiliations

  1. 1.University of Florida College of MedicineGainesvilleUSA

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