Intestinal Failure and Parenteral Omega-3 Fatty Acid Lipid Emulsions

Reference work entry


Intestinal failure will occur in intensive care patients, necessitating the use of parenteral nutrition. It is not known how commonly such patients will develop intestinal failure-associated liver disease (IFALD). Furthermore, liver disease is observed in intensive care patients, independent of parenteral nutrition. Therefore, it is not clear if omega-3 lipid emulsions will benefit intensive care patients, to improve liver disease, as now reported in IFALD. However, omega-3 lipid emulsions may have other benefits in critically ill patients, including immune modulation and reduction in oxidative stress. At this time it is not clear if the benefits for IFALD, or indeed for immune function, are specifically related to the addition of omega-3 lipid or to concomitant reduction in omega-6 lipid.


Parenteral Nutrition Enteral Nutrition Short Bowel Syndrome Lipid Emulsion Essential Fatty Acid Deficiency 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

List of Abbreviations


Arachidonic acid


Bile salt export pump




Docosahexaenoic acid


Essential fatty acid deficiency


Enteral nutrition


Eicosapentaenoic acid




Intensive care/intensive care unit


Intestinal failure-associated liver disease


Intravenous lipid emulsion


Linolenic acid


Long-chain polyunsaturated fatty acid




Medium-chain triglyceride


Pediatric intensive care or intensive care unit


Parenteral nutrition


Parenteral nutrition-associated liver disease


Thromboxane A2


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Copyright information

© Her Majesty the Queen in Right of Canada 2015

Authors and Affiliations

  1. 1.Division of Pediatric Gastroenterology and Nutrition, Department of PediatricsUniversity of AlbertaEdmontonCanada
  2. 2.Group for Improvement of Intestinal Function and Treatment (GIFT), Division of General and Thoracic SurgeryThe Hospital for Sick ChildrenTorontoCanada

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