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l-Alanyl-l-glutamine Dipeptide-Supplemented Total Parenteral Nutrition

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Diet and Nutrition in Critical Care

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Abstract

Glutamine is the most abundant free amino acid in the human body. It plays an important role in cellular metabolism and proliferation, as well as in immune regulation. It has been considered as “conditionally essential” in critical illnesses. The benefits behind using parenteral nutrition supplemented with glutamine on critically ill patients have received extensive support for many years from in vitro studies, animal models, and human studies. All of these have been further reinforced through systematic reviewing and meta-analysis. However, results from recent studies indicate that its prescription is controversial, it could be non-beneficial, and it may even be harmful if the patient type, timing, and dosage are not carefully selected.

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Abbreviations

Gln:

Glutamine

ICU:

Intensive care unit

MODS:

Multiple organ dysfunction syndrome

PN:

Parenteral nutrition

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Author information

Authors and Affiliations

  1. Intensive Care Unit, Hospital Sur de Alcorcon, Estanbul 30, 28922, Alcorcon, Madrid, Spain

    José Luis Flordelís Lasierra

  2. Department of Intensive Care, Hospital Universitario Doce de Octubre, Av. Andalucía s/n, 28041, Madrid, Spain

    Teodoro Grau Carmona

Authors
  1. José Luis Flordelís Lasierra
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  2. Teodoro Grau Carmona
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Corresponding author

Correspondence to José Luis Flordelís Lasierra .

Editor information

Editors and Affiliations

  1. Royal Free London Hospitals, Barnet General Hospital, London, UK

    Rajkumar Rajendram

  2. Division of Diabetes & Nutritional Sciences, Faculty of Life Sciences & Medicine, King’s College London, London, UK

    Rajkumar Rajendram

  3. King Khalid University Hospital, King Saud University Medical City, Riyadh, Saudi Arabia

    Rajkumar Rajendram

  4. Department of Nutrition and Dietetics, Division of Diabetes & Nutritional Sciences, Faculty of Life Sciences & Medicine, King’s College London, London, UK

    Victor R. Preedy

  5. Department of Biomedical Sciences, Faculty of Science & Technology, University of Westminster, London, UK

    Vinood B. Patel

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© 2015 Springer Science+Business Media New York

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Lasierra, J.L.F., Carmona, T.G. (2015). l-Alanyl-l-glutamine Dipeptide-Supplemented Total Parenteral Nutrition. In: Rajendram, R., Preedy, V.R., Patel, V.B. (eds) Diet and Nutrition in Critical Care. Springer, New York, NY. https://doi.org/10.1007/978-1-4614-7836-2_59

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  • DOI: https://doi.org/10.1007/978-1-4614-7836-2_59

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  • Publisher Name: Springer, New York, NY

  • Print ISBN: 978-1-4614-7837-9

  • Online ISBN: 978-1-4614-7836-2

  • eBook Packages: MedicineReference Module Medicine

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