Abstract
Loss of lean tissue appears to be a normal part of critical illness, but can profoundly affect the patient’s outcome, demanding careful attention to the nutritional prescription including protein intakes in particular. However, nutrient intake recommendations in the intensive care setting are based on low levels of evidence. Protein requirements, in particular, are difficult to define due to the multiplicity of confounding factors (including energy intake) as well as, in the critically ill, the metabolic alterations that occur in trauma, sepsis, and inflammation. In general, studies seem to suggest that there is little difference between outcomes with protein intakes of 1.1–2.2 g per kilogram body weight, and below this level may not be ideal. However, the limited availability of high-level evidence, and the significant heterogeneity within the critical care population, indicates a need for further research. Identifying parameters with which to monitor a patient’s nutritional progress might be even more valuable, enabling an individualized prescription to be adjusted according to the patient’s condition. Methods in current use, such as anthropometric measures, tests of muscle function, and laboratory parameters, all have significant limitations.
Access this chapter
Tax calculation will be finalised at checkout
Purchases are for personal use only
References
A’Beckett K, Baytieh L, Carr-Thompson A, Fox V, MacLennan P, Marriott J, Nicholls C, Petrunoff N. NSW Statewide Burn Injury Service clinical practice guidelines for burn patient nutrition management. Chatswood: NSW Agency for Clinical Innovation (ACI); 2011.
Allison SP. The uses and limitations of nutritional support. Clin Nutr. 1992;11:319–30.
Arnold J, Campbell IT, Samuels TA, et al. Increased whole body protein breakdown predominates over increased whole body protein synthesis in multiple organ failure. Clin Sci. 1993;84:655–61.
Bastow MD, Rawlings J, Allison SP. Benefits of supplementary tube feeding after fractured neck of femur: a randomised controlled trial. Br Med J. 1983;287:1589–92.
Birkhahn RH, Long CL, Fitkin D, Geiger JW, Blakemore WS. Effects of major skeletal trauma on whole body protein turnover in man measured by l-[1,14C]-leucine. Surgery. 1980;88:294–9.
Calloway DH, Spector H. Nitrogen balance is related to caloric and protein intake in active young men. Am J Clin Nutr. 1954;2:405–12.
Campbell WW, Trappe TA, Wolfe RR, Evans WJ. The recommended dietary allowance for protein may not be adequate for older people to maintain skeletal muscle. J Gerontol A Biol Sci Med Sci. 2001;56A:M373–80.
Christie PM, Hill GL. Effect of intravenous nutrition on nutrition and function in acute attacks of inflammatory bowel disease. Gastroenterology. 1990;99(3):730–6.
Clague MB, Keir MJ, Wright PD, Johnston ID. The effects of nutrition and trauma on whole-body protein metabolism in man. Clin Sci. 1983;65(2):165–75.
Clark MA, Hentzen BTH, Plank LD, Hill GL. Sequential changes in insulin-like growth factor 1, plasma proteins, and total body protein in severe sepsis and multiple injury. JPEN. 1996;20(5):363–70.
Clifton GL, Robertson CS, Contant CF. Enteral hyperalimentation in head injury. J Neurosurg. 1985;62:186–93.
Coakley JH, Nagendran K, Honavar M, Hinds CJ. Preliminary observations on the neuromuscular abnormalities in patients with organ failure and sepsis. Intensive Care Med. 1993;19(6):323–8.
Colley CM, Fleck A, Goode AW, Muller BR, Myers MA. Early time course of the acute phase protein response in man. J Clin Pathol. 1983;36:203–7.
D’Alessio DA, Kavle EC, Mozzoli MA, et al. Thermic effect of food in lean and obese men. J Clin Invest. 1988;81:1781–9.
ESPEN (European Society for Clinical Nutrition and Metabolism). ESPEN guidelines on enteral nutrition. Clin Nutr. 2006;25(2):180–360.
ESPEN (European Society for Clinical Nutrition and Metabolism). ESPEN guidelines on parenteral nutrition. Clin Nutr. 2009;28(4):359–479.
Finn PJ, Plank LD, Clark MA, Connolly AB, Hill GL. Assessment of involuntary muscle function in patients after critical injury or severe sepsis. JPEN. 1996;20(5):332–7.
Fleck A. Plasma proteins as nutritional indicators in the perioperative period. Br J Clin Pract. 1988;42 suppl 63:20–4.
Goldberg AL. Protein turnover in skeletal muscle: effects of denervation and cortisone on protein catabolism in skeletal muscle. J Biol Chem. 1969;244(12):3223–9.
Goldspink DF. The influence of activity on muscle size and protein turnover. J Physiol. 1977;264:283–96.
Gore DC, Jahoor F, Wolfe RR, Herndon DN. Acute response of human muscle protein to catabolic hormones. Ann Surg. 1993;218:679–94.
Greig PD, Elwyn DH, Askanazi J, Kinney JM. Parenteral nutrition in septic patients: effect of increasing nitrogen intake. Am J Clin Nutr. 1987;46:1040–7.
Hart DW, Wolf SE, Herndon DN, et al. Energy expenditure and caloric balance after burn: increased feeding leads to fat rather than lean mass accretion. Ann Surg. 2002;235:152–61.
Hasselgren PO, Pedersen P, Sax HC, Warner BW, Fischer JE. Current concepts of protein turnover and amino acid transport in liver and skeletal muscle during sepsis. Arch Surg. 1988;123:992–9.
Haydock DA, Hill GL. Impaired wound healing in surgical patients with varying degrees of malnutrition. JPEN. 1986;10:550–4.
Helliwell TR, Coakley JH, Wagenmakers AJM, Griffiths RD, Campbell IT, Green CJ, McClelland P, Bone JM. Necrotizing myopathy in critically-ill patients. J Pathol. 1991;164:307–14.
Heyland DK, Dhaliwal R, Jiang X, Day AG. Identifying critically ill patients who benefit the most from nutrition therapy: the development and initial validation of a novel risk assessment tool. Crit Care. 2011;15:R268.
Hill GL, Jonathan E. Rhoads lecture: body composition research: implications for the practice of clinical nutrition. JPEN. 1992;16(3):197–218.
Huang SL, Lee ST. Nutritional care of severe acute head injury patients: formulas for early enteral alimentation. J Formos Med Assoc. 1990;89(6):498–503.
Institute of Medicine (IOM). Nutrition and traumatic brain injury: improving acute and subacute health outcomes in military personnel. Washington DC: National Academies Press; 2011.
International Committee on Radiological Protection. Report of the task force on reference man. Oxford: Pergamon; 1975. Report No. 23.
Ishibashi N, Plank LD, Sando K, Hill GL. Optimal protein requirements during the first 2 weeks after the onset of critical illness. Crit Care Med. 1998;26(9):1529–35.
Jeejeebhoy KN. Rhoads lecture 1988: Bulk or bounce? – the object of nutritional support. JPEN. 1988;12(6):539–49.
Jequier E. Thermogenesis induced by nutrient administration in man. Infusionstherapie. 1984;11:184–8.
Klidjian AM, Foster KJ, Kammerling RM, et al. Relation of anthropometric and dynamometric variables to serious postoperative complications. Br Med J. 1980;281:899–900.
Klidjian AM, Archer TJ, Foster JK, Karran SJ. Detection of dangerous malnutrition. JPEN. 1982;6:119–21.
Larsson J, Lennmarken C, Mårtensson J, Sandstedt S, Vinnars E. Nitrogen requirements in severely injured patients. Br J Surg. 1990;77(4):413–16.
Long CL, Jeevanandam M, Kim BM, Kinney JM. Whole body protein synthesis and catabolism in septic man. Am J Clin Nutr. 1977;30:1340–4.
Mariotti F, Daniel Tomé D, Mirand PP. Converting nitrogen into protein – beyond 6.25 and Jones’ factors. Crit Rev Food Sci Nutr. 2008;48(2):177–84.
McClave SA, Martindale RG, Vanek VW, et al. ASPEN Guidelines for the provision and assessment of nutrition support therapy in the adult critically ill patient. JPEN. 2009;33(3):277–316.
McCowen KC, Friel C, Sternberg J, Chan S, Forse RA, Burke PA, Bistrian BR. Hypocaloric total parenteral nutrition: effectiveness in prevention of hyperglycemia and infectious complications – a randomized clinical trial. Crit Care Med. 2000;28(11):3606–11.
Mesejo A, Acosta JA, Ortega YC, Vila NJ, Fernałndez ZM, Ferreres YJ, Sanchis NJC, Lopez NF. Comparison of a high-protein disease-specific enteral formula with a high-protein enteral formula in hyperglycemic critically ill patients. Clin Nutr. 2003;22(3):295–305.
Millward DJ. An adaptive metabolic demand model for protein and amino acid requirements. Br J Nutr. 2003;90(2):249–60.
Monk DN, Plank LD, Franch-Arcas G, Finn PJ, Streat SJ, Hill GL. Sequential changes in the metabolic response in critically injured patients during the first 25 days after blunt trauma. Ann Surg. 1996;223(4):395–405.
Munro HN. General aspects of the regulation of protein metabolism by diet and by hormones. In: Munro HN, Allison JB, editors. Mammalian protein metabolism. New York: Academic; 1964.
NICE. Nutrition support in adults – oral nutrition support, enteral tube feeding and parenteral nutrition (clinical guideline 32). NHS National Collaborating Centre for Acute Care UK, 2006.
O’Keefe SJD, Sender PM, James WPT. ‘Catabolic’ loss of body nitrogen in response to surgery. Lancet. 1974;2:1035–8.
Rand WM, Pellett PL, Young VR. Meta-analysis of nitrogen balance studies for estimating protein requirements in healthy adults. Am J Clin Nutr. 2003;77:109–27.
Rennie MJ. Muscle protein turnover and the wasting due to injury and disease. Br Med Bull. 1985;41(3):257–64.
Scheinkestel CD, Kar L, Marshall K, Bailey M, Davies A, Nyulasi I, Tuxen DV. Prospective randomized trial to assess caloric and protein needs of critically ill, anuric, ventilated patients requiring continuous renal replacement therapy. Nutrition. 2003;19(11–12):909–16.
Serog P, Baigts F, Apfelbaum M. Energy and nitrogen balances in 24 severely burned patients receiving four isocaloric diets of about 10MJ/m2/day (2392 kcalories/m2/day). Burns. 1982;9(6):422–7.
Shaw JHF, Wolfe RR. An integrated analysis of glucose, fat and protein metabolism in severely traumatised patients. Studies in the basal state and the response to total parenteral nutrition. Ann Surg. 1989;209(1):63–72.
Shaw JHF, Wildbore M, Wolfe RR. Whole body protein kinetics in severely septic patients. Ann Surg. 1987;205:288–94.
Snell R. Dietitians’ pocket book. Perth: Curtin University of Technology School of Public Health; 2006.
Stewart R. Griffith handbook of clinical nutrition & dietetics. 3rd ed. Southport: Griffith University School of Public Health; 2009.
Streat SJ, Beddoe AH, Hill GL. Aggressive nutritional support does not prevent protein loss despite fat gain in septic intensive care patients. J Trauma. 1987;27:262–6.
Stroud M. Protein and the critically ill; do we know what to give? Proc Nutr Soc. 2007;66(3):378–83.
Tentolouris N, Pavlatos S, Kokkinos A, Perrea D, Pagoni S, Katsilambros N. Diet-induced thermogenesis and substrate oxidation are not different between lean and obese women after two different isocaloric meals, one rich in protein and one rich in fat. Metab Clin Exp. 2008;57(3):313–20.
Trans-Tasman Dietetic Wound Care Group. Evidence based practice guidelines for the dietetic management of adults with pressure injuries. DAA and DNZ, 2011.
Twyman D, Young AB, Ott L, Norton JA, Bivins BA. High protein enteral feedings: a means of achieving positive nitrogen balance in head injured patients. JPEN. 1985;9(6):679–84.
van der Heijden A, Verbeek MJ, Schreurs VV, Akkermans LM, Vos A. Effect of increasing protein ingestion on the nitrogen balance of mechanically ventilated critically ill patients receiving total parenteral nutrition. Nutr Hosp. 1993;8(5):279–87.
Weijs PJM, Sauerwein HP, Kondrup J. Protein recommendations in the ICU: g protein/kg body weight – which body weight for underweight and obese patients? Clin Nutr. 2012;31:774–5.
Wilmore DW. Catabolic illness: strategies for enhancing recovery. N Engl J Med. 1991;325(10):695–702.
Windsor JA, Hill GL. Protein depletion and surgical risk. Aust N Z J Surg. 1988a;58:711–15.
Windsor JA, Hill GL. Risk factors for postoperative pneumonia: the importance of protein depletion. Ann Surg. 1988b;208(2):209–14.
Windsor JA, Hill GL. Grip strength: a measure of the proportions of protein loss in surgical patients. Br J Surg. 1988c;75:880–2.
Windsor JA, Knight GS, Hill GL. Wound healing response in surgical patients: recent food intake is more important than nutritional status. Br J Surg. 1988;75:135–7.
Witt NJ, Zochodne DW, Bolton CF, Grand’Maison F, Wells G, Young GB, Sibbald WJ. Peripheral nerve function in sepsis and multiorgan failure. Chest. 1991;99(1):176–84.
Wolfe RR, Goodenough RD, Burke JF, Wolfe MH. Response of protein and urea kinetics in burn patients to different levels of protein intake. Ann Surg. 1982;197(2):163–71.
World Health Organization. Food and Agriculture Organization of the United Nations, and United Nations University. Protein and amino acid requirements in human nutrition: report of a joint WHO/FAO/UNU expert consultation. Geneva: WHO Technical Report Series 935; 2002.
Author information
Authors and Affiliations
Corresponding author
Editor information
Editors and Affiliations
Rights and permissions
Copyright information
© 2015 Springer Science+Business Media New York
About this entry
Cite this entry
Ferrie, S., Rand, S. (2015). Protein Intake in Critically Ill Adults. In: Rajendram, R., Preedy, V.R., Patel, V.B. (eds) Diet and Nutrition in Critical Care. Springer, New York, NY. https://doi.org/10.1007/978-1-4614-7836-2_4
Download citation
DOI: https://doi.org/10.1007/978-1-4614-7836-2_4
Published:
Publisher Name: Springer, New York, NY
Print ISBN: 978-1-4614-7837-9
Online ISBN: 978-1-4614-7836-2
eBook Packages: MedicineReference Module Medicine