Effects of Nutrition on Neutrophil Function in Preclinical Studies

  • Keisuke Kohama
  • Joji Kotani
  • Atsunori Nakao
Reference work entry


Although neutrophils are an essential component of natural immunity, their activities must be carefully regulated to prevent detrimental prolonging of inflammation. To resolve inflammation, neutrophil recruitment to the affected tissue must be blocked, and neutrophils in the tissue must be removed by apoptosis and phagocytosis. Polyunsaturated fatty acids (PUFAs) are a major dietary regulator of immune function. N-3 PUFAs and n-6 PUFAs modulate the inflammatory response in neutrophils. N-3 PUFA exhibits anti-inflammatory activities through neutrophils using multiple mechanisms including decreasing neutrophil chemotaxis in response to inflammatory stimuli, reducing neutrophil adhesion to the vascular endothelium and neutrophil transmigration across the endothelium and into the affected tissue, and promotes the synthesis of resolvins and protectins, inflammation-resolving lipids that promote neutrophil apoptosis and phagocytosis. Sepsis and acute respiratory distress syndrome, common conditions in critical care patients, are both a result of dysregulated or excessive inflammation. Preclinical data obtained from rodent models and cell culture studies support a role in nutritional immunomodulation using n-3 PUFAs or their derivatives in patients with sepsis or acute lung injury.


Acute Lung Injury Parenteral Nutrition Systemic Inflammatory Response Syndrome Multiple Organ Dysfunction Syndrome Lipid Mediator 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

List of Abbreviations


Acute respiratory distress syndrome




Docosahexaenoic acid


Eicosapentaenoic acid


Granulocyte-colony stimulating factor


Granulocyte–macrophage colony-stimulating factor


Intercellular adhesion molecule 1








Leukotriene B4


Leukotriene B5




Prostaglandin D2


Prostaglandin D3


Prostaglandin E2


Polymorphonuclear cell


Polyunsaturated fatty acids


Reactive oxygen species


Resolvin D1


Resolvin D2


Resolvin E1


Systemic inflammatory response syndrome


Tumor necrosis factor-α




Vascular cell adhesion molecule 1


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Copyright information

© Springer Science+Business Media New York 2015

Authors and Affiliations

  1. 1.Department of Emergency, Disaster and Critical Care MedicineHyogo College of MedicineNishinomiyaJapan

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