Definition
Models of neuron types of the striatum, which include details of ion channels and neuron morphology.
Detailed Description
Striatal Function in Disease and Health
The striatum is the main input structure of the basal ganglia and is implicated in habit learning, addiction, and neuropathologies such as Parkinson’s disease and Huntington’s disease. Parkinson’s disease is a motor dysfunction caused by degeneration of dopaminergic neurons that project strongly to the striatum. Huntington’s disease is another motor dysfunction caused by degeneration of a subset of the neurons in the striatum. Experiments in both humans and animals have demonstrated that normal habit learning involves the striatum, and changes in striatal neural activity are observed consequent to cortical glutamatergic activity (in response to environmental stimuli or motor activity) and dopamine release in response to reward.
Cell Classes in the Striatum
The projection neurons of the striatum are the medium spiny...
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References
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Blackwell, K.T., Damodaran, S., Evans, R. (2014). Striatal Models, Cellular Detail. In: Jaeger, D., Jung, R. (eds) Encyclopedia of Computational Neuroscience. Springer, New York, NY. https://doi.org/10.1007/978-1-4614-7320-6_88-1
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DOI: https://doi.org/10.1007/978-1-4614-7320-6_88-1
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Publisher Name: Springer, New York, NY
Online ISBN: 978-1-4614-7320-6
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Chapter history
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Latest
Basal Ganglia: Striatal Models Cellular Detail- Published:
- 07 October 2019
DOI: https://doi.org/10.1007/978-1-4614-7320-6_88-2
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Original
Striatal Models, Cellular Detail- Published:
- 13 March 2014
DOI: https://doi.org/10.1007/978-1-4614-7320-6_88-1