Skip to main content
SpringerLink
Log in
Book cover

Encyclopedia of Computational Neuroscience pp 1–2Cite as

Neuromodulation: Overview

  • Living reference work entry
  • First Online:

  • 228 Accesses

Definition

Neuromodulation refers to the regulation of neural and synaptic function by regulatory extrinsic or intrinsic substances.

Detailed Description

Computational modeling of neural substrates provides an excellent theoretical framework for the understanding of the computational roles of neuromodulation. Neuromodulation can be defined as biophysical processes that serve to modify – or modulate – the computation performed by a neuron or network as a function of task demands and behavioral state of the animal. These modulatory effects often involve substances such as acetylcholine (ACh), norepinephrine (NE), histamine, serotonin (5-HT), dopamine (DA), and a variety of neuropeptides. Modulatory effects are difficult to define, because they often originate from different structures and have different spatial distributions and time courses of action. Because of the wider use of modeling techniques and growing interest in systems neuroscience, the computational role of neuromodulation...

This is a preview of subscription content, log in via an institution.

References

  • Fellous JM, Linster C (1998) Computational models of neuromodulation. Neural Comput 10(4):771–805

    Google Scholar 

Further Reading

  • Dayan P (2012) Twenty-five lessons from computational neuromodulation. Neuron 76(1):240–256. doi:10.1016/j.neuron.2012.09.027

    Article  CAS  PubMed  Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Computational Physiology Lab, Department of Neurobiology & Behavior, Cornell University, Ithaca, NY, USA

    Christiane Linster

Authors
  1. Christiane Linster
    View author publications

    You can also search for this author in PubMed Google Scholar

Corresponding author

Correspondence to Christiane Linster .

Editor information

Editors and Affiliations

  1. Atlanta, Georgia, USA

    Dieter Jaeger

  2. Department of Biomedical Engineering, Florida International University, Miami, Florida, USA

    Ranu Jung

Rights and permissions

Reprints and permissions

Copyright information

© 2014 Springer Science+Business Media New York

About this entry

Cite this entry

Linster, C. (2014). Neuromodulation: Overview. In: Jaeger, D., Jung, R. (eds) Encyclopedia of Computational Neuroscience. Springer, New York, NY. https://doi.org/10.1007/978-1-4614-7320-6_787-1

Download citation

  • DOI: https://doi.org/10.1007/978-1-4614-7320-6_787-1

  • Received:

  • Accepted:

  • Published:

  • Publisher Name: Springer, New York, NY

  • Online ISBN: 978-1-4614-7320-6

  • eBook Packages: Springer Reference Biomedicine and Life SciencesReference Module Biomedical and Life Sciences

Publish with us

Policies and ethics

Search

Navigation