Sleep, Neural Population Models of
A neural population model of sleep is a mathematical model of neural populations that regulate the timing and expression of sleep/wake patterns. Specific circuits and nuclei have been identified in the mammalian brainstem and hypothalamus that play a key role in modulating the brain’s overall arousal state with a circadian (daily) rhythm. These neural populations have been the focus of most sleep modeling.
Sleep is an arousal state characterized by physical inactivity, reduced sensitivity to environmental stimuli, and a range of characteristic physiological changes, including changes to the EEG associated with rapid eye movement (REM) and non-REM (NREM) sleep in mammals. Sleep is regulated by a variety of physiological and biochemical processes (Krueger et al. 2008; Saper et al. 2010), including specific neural populations in the brainstem and hypothalamus. Various mathematical models have now been developed, providing a conduit between the underlying...
KeywordsArousal State Neural Population Wake State Homeostatic Process Human Sleep
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