Encyclopedia of Computational Neuroscience

Living Edition
| Editors: Dieter Jaeger, Ranu Jung

Sleep, Neural Population Models of

  • Andrew J. K. Phillips
Living reference work entry
DOI: https://doi.org/10.1007/978-1-4614-7320-6_76-1


A neural population model of sleep is a mathematical model of neural populations that regulate the timing and expression of sleep/wake patterns. Specific circuits and nuclei have been identified in the mammalian brainstem and hypothalamus that play a key role in modulating the brain’s overall arousal state with a circadian (daily) rhythm. These neural populations have been the focus of most sleep modeling.

Detailed Description

Sleep is an arousal state characterized by physical inactivity, reduced sensitivity to environmental stimuli, and a range of characteristic physiological changes, including changes to the EEG associated with rapid eye movement (REM) and non-REM (NREM) sleep in mammals. Sleep is regulated by a variety of physiological and biochemical processes (Krueger et al. 2008; Saper et al. 2010), including specific neural populations in the brainstem and hypothalamus. Various mathematical models have now been developed, providing a conduit between the underlying...


Arousal State Neural Population Wake State Homeostatic Process Human Sleep 
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Further Reading

  1. Hutt A (2011) Sleep and anesthesia. Springer, New YorkCrossRefGoogle Scholar
  2. Steyn-Ross DA, Steyn-Ross ML (2010) Modeling phase transitions in the brain. Springer, New YorkCrossRefGoogle Scholar
  3. Scholarpedia Google Scholar
  4. Neurobiology of sleep and wakefulnessGoogle Scholar
  5. Sleep homeostasisGoogle Scholar
  6. Wikipedia Google Scholar
  7. Circadian rhythmGoogle Scholar
  8. Neuroscience of sleepGoogle Scholar
  9. Suprachiasmatic nucleusGoogle Scholar

Copyright information

© Springer Science+Business Media New York 2013

Authors and Affiliations

  1. 1.Division of Sleep Medicine, Brigham and Women’s HospitalHarvard Medical SchoolBostonUSA