Definition
Modelling ion fluctuations will permit better understanding of the role of perturbed ion homeostasis in the pathophysiology of nervous system diseases and will assist in guiding therapeutic interventions.
Description
The impact of ion channel gating has been modelled in great detail through colossal efforts invested by the neurocomputation community (Hines et al. 2004). However, understanding ion dynamics in itself bears equal importance as a crucial determinant of transmembrane currents. Modulation and disruption of ion homeostasis plays a critical role in development, signaling, and in the pathophysiology of several diseases of the nervous system (De Koninck 2006). Since ion homeostasis is determined by the interaction between synaptic inputs, ion channels, and the activity of pumps and transporters, understanding the latter is of the utmost importance. These studies however raise many experimental difficulties because specific ion fluctuations are more difficult to...
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Doyon, N., Castonguay, A., De Koninck, Y. (2014). Neuropharmacological Modelling: Alterations in Ionic Homeostasis. In: Jaeger, D., Jung, R. (eds) Encyclopedia of Computational Neuroscience. Springer, New York, NY. https://doi.org/10.1007/978-1-4614-7320-6_750-1
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DOI: https://doi.org/10.1007/978-1-4614-7320-6_750-1
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